Solid tumours hijack the histone variant network
- 10 February 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Cancer
- Vol. 21 (4), 257-275
- https://doi.org/10.1038/s41568-020-00330-0
Abstract
Cancer is a complex disease characterized by loss of cellular homeostasis through genetic and epigenetic alterations. Emerging evidence highlights a role for histone variants and their dedicated chaperones in cancer initiation and progression. Histone variants are involved in processes as diverse as maintenance of genome integrity, nuclear architecture and cell identity. On a molecular level, histone variants add a layer of complexity to the dynamic regulation of transcription, DNA replication and repair, and mitotic chromosome segregation. Because these functions are critical to ensure normal proliferation and maintenance of cellular fate, cancer cells are defined by their capacity to subvert them. Hijacking histone variants and their chaperones is emerging as a common means to disrupt homeostasis across a wide range of cancers, particularly solid tumours. Here we discuss histone variants and histone chaperones as tumour-promoting or tumour-suppressive players in the pathogenesis of cancer.Keywords
This publication has 296 references indexed in Scilit:
- Modulation of HJURP (Holliday Junction-Recognizing Protein) Levels Is Correlated with Glioblastoma Cells SurvivalPLOS ONE, 2013
- Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomasActa Neuropathologica, 2013
- K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomasActa Neuropathologica, 2012
- Association of Age at Diagnosis and Genetic Mutations in Patients With NeuroblastomaJAMA, 2012
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent DioxygenasesCancer Cell, 2011
- Function and metabolism of sirtuin metabolite O-acetyl-ADP-riboseBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2010
- HJURP Is a Cell-Cycle-Dependent Maintenance and Deposition Factor of CENP-A at CentromeresCell, 2009
- Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURPCell, 2009
- Principles of Cancer Therapy: Oncogene and Non-oncogene AddictionCell, 2009
- H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage CommitmentCell, 2008