Long Noncoding RNAs: Novel Important Players in Adipocyte Lipid Metabolism and Derivative Diseases
Open Access
- 8 June 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Physiology
Abstract
Obesity, a global public health issue, is characterized by excessive adiposity and is strongly related to some chronic diseases including cardiovascular diseases and diabetes. Extra energy intake-induced adipogenesis involves various transcription factors and long noncoding RNAs (lncRNAs) that control lipogenic mRNA expression. Currently, lncRNAs draw much attention for their contribution to adipogenesis and adipose tissue function. Increasing evidence also manifests the pivotal role of lncRNAs in modulating white, brown, and beige adipose tissue development and affecting the progression of the diseases induced by adipose dysfunction. The aim of this review is to summarize the roles of lncRNAs in adipose tissue development and obesity-caused diseases to provide novel drug targets for the treatment of obesity and metabolic diseases.This publication has 118 references indexed in Scilit:
- PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cellsNature, 2012
- Inflammation and Lipid Signaling in the Etiology of Insulin ResistanceCell Metabolism, 2012
- Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin InteractionsMolecular Cell, 2011
- Molecular Mechanisms of Long Noncoding RNAsMolecular Cell, 2011
- siRNA Off-Target Effects Can Be Reduced at Concentrations That Match Their Individual PotencyPLOS ONE, 2011
- Adipose tissue remodeling and obesityJCI Insight, 2011
- Functional Characterization of the Plasmacytoma Variant Translocation 1 Gene (PVT1) in Diabetic NephropathyPLOS ONE, 2011
- A long noncoding RNA maintains active chromatin to coordinate homeotic gene expressionNature, 2011
- Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammalsNature, 2009
- A Strategy for Probing the Function of Noncoding RNAs Finds a Repressor of NFATScience, 2005