Overview of the Determination of Captopril Levels in Pharmaceutical Preparations and Biological Matrices

Abstract

Captopril is the most commonly prescribed ACE-Inhibitor class of drugs because it is easily accessible and affordable. Therefore, to ensure drug quality, captopril levels were determined. This review article aims to provide an overview of the various analytical techniques that have been carried out in selecting the groups of captopril in both pharmaceutical dosage forms and biological matrices. Some of these analytical methods include the UV-Visible spectrophotometric method, high-performance liquid chromatography (HPLC), voltammetry, and flow injection. The data collection process in this review article is to collect research journals through trusted sites in the last ten years (2011-2021) with the search keywords "Determination of Captopril," "Analysis of Captopril on Pharmaceutical Preparations," and Analysis of Captopril on Biological Matrices." From the data that has been collected, the voltammetric method is the most widely used analytical technique in determining captopril for both pharmaceutical preparations and biological matrices in the last ten years.