Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021
- 6 March 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in The Journal of Antibiotics
- Vol. 73 (6), 365-371
- https://doi.org/10.1038/s41429-020-0292-7
Abstract
Three new antimalarial compounds, clonocoprogens A, B, and C, were isolated from the static culture of an Okinawan fungus, Clonostachys compactiuscula FKR-0021. These compounds were new analogs of N14-palmitoylcoprogen, reported as a siderophore. They showed moderate antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC50 values ranging from 1.7 to 9.9 µM.Keywords
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