Cervical and oral human papillomavirus infection in women living with human immunodeficiency virus (HIV) and matched HIV-negative controls in Brazil
Open Access
- 11 May 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Infectious Agents and Cancer
- Vol. 15 (1), 1-11
- https://doi.org/10.1186/s13027-020-00301-y
Abstract
Despite the demonstrated role of human Papillomavirus (HPV) in the etiology of cervical cancer and the strong evidence suggesting the importance of HPV in the development of oropharyngeal cancer, several aspects of the interrelationship between HPV infection in both body sites remain unknown, specifically in female human immunodeficiency virus (HIV)-positive (HIV+) patients. We aimed to assess the prevalence, distribution, and concordance of cervical and oral HPV in HIV+ women and matched HIV-negative (HIV-) controls in Brazil. Cervical and endocervical samples for cytological screening and HPV detection and oral samples were collected from 115 HIV+ women using highly active antiretroviral therapy (HAART) and 139 HIV-matched controls (HIV-) in Maringá City, Brazil. Risk factors were assessed using a standardized questionnaire, and the data regarding HIV infection were obtained from the patients’ medical records. HPV detection and typing were performed using the Kit Multiplex XGEN Multi HPV Chip HS12. HIV infection was well controlled in this cohort, but women who exhibited detectable HIV loads were significantly associated with HPV-positive status overall (P = 0.03) and in cervical mucosa (P = 0.01). HIV+ women had significantly more abnormal cytological findings (P = 0.04) than HIV- women. Of the 115 HIV+ women, 48.7% were positive for cervical and/or oral HPV DNA; of the 139 HIV- women, 41% were positive for cervical and/or oral HPV (P = 0.25). Both HIV+ and HIV- women had a statistically higher prevalence of cervical HPV infection than oral infection. The concurrent HPV infection in two anatomical sites was similar in HIV+ and HIV- women; however, HPV type concordance was not observed. HPV type distribution was different between the anatomical sites in both groups, and HIV+ women presented less common types, mainly in oral mucosa. Our data support the importance of testing HPV infection in HIV+ women, even when the HIV infection is well controlled. Prospective studies are required to better understand the natural history of HPV infection in both anatomical sites, specifically in HIV+ women.Keywords
Other Versions
Funding Information
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (P30CA013148-43S2)
This publication has 45 references indexed in Scilit:
- Prevalence of human papillomavirus genotypes in HIV-1-infected women in Seattle, USA and Nairobi, Kenya: results from the Women's HIV Interdisciplinary Network (WHIN)International Journal of Infectious Diseases, 2010
- The Human Papillomavirus Type 16 E6 Oncoprotein Activates mTORC1 Signaling and Increases Protein SynthesisJournal of Virology, 2010
- Epidemiological Data of Different Human Papillomavirus Genotypes in Cervical Specimens of HIV-1-Infected Women Without History of Cervical PathologyJAIDS Journal of Acquired Immune Deficiency Syndromes, 2009
- Human papillomavirus-related disease in people with HIVCurrent Opinion in HIV and AIDS, 2009
- Human papilloma virus types in the oral and cervical mucosa of HIV‐positive South African women prior to antiretroviral therapyJournal of Oral Pathology & Medicine, 2008
- Human papillomavirus-related diseases in HIV-infected individualsCurrent Opinion in Oncology, 2008
- Cervical and oral human papillomavirus types in HIV‐1 positive and negative women with cervical disease in South AfricaJournal of Medical Virology, 2008
- Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and SmokingInternational Journal of Radiation Oncology*Biology*Physics, 2007
- Six‐month natural history of oral versus cervical human papillomavirus infectionInternational Journal of Cancer, 2007
- Relationship between Prevalent Oral and Cervical Human Papillomavirus Infections in Human Immunodeficiency Virus-Positive and -Negative WomenJournal of Clinical Microbiology, 2006