Sedative effects of inhaled Perilla frutescens essential oils on mice
- 12 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Natural Medicines
- Vol. 75 (3), 664-669
- https://doi.org/10.1007/s11418-021-01482-5
Abstract
Perilla frutescens is an ingredient for cooking and for Japanese traditional medicine formulations. Essential oils extracted from P. frutescens are classified according to their composition, which are genetically regulated. Here, we extracted five types of essential oil from P. frutescens and studied their sedative activities. We grew P. frutescens strains that give oils of type PK, PA, PP, EK, and C, and extracted the essential oils by hydrodistillation. We then measured the spontaneous locomotor activity of mice who had inhaled the oils in an open field test. All types of essential oil except the PK type decreased the spontaneous locomotor activity of mice. The effective doses were 4.0 × 10−3 to 4.0 × 10−2 mg/cage (PA type), 4.0 × 10−4 mg/cage (PP type), 4.0 × 10−5 mg/cage (EK type), and 4.0 × 10−5 to 4.0 × 10−3 mg/cage (C type). Our results show that the essential oils of type PA, PP, EK, and C have a sedative effect.Keywords
This publication has 11 references indexed in Scilit:
- Sedative effects of the essential oil from the leaves of Lantana camara occurring in the Republic of Benin via inhalation in miceJournal of Natural Medicines, 2019
- Sedative effects of the essential oil and headspace air of Ocimum basilicum by inhalation in miceJournal of Natural Medicines, 2018
- Locomotor-Reducing Activity of Sesquiterpenes Related to Zingiber zerumbet Essential Oil and Hexahydrozerumbone DerivativesBiological & Pharmaceutical Bulletin, 2016
- Synergistic Effect of Fragrant Herbs in Japanese Scent SachetsPlanta Medica, 2015
- Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in miceJournal of Ethnopharmacology, 2013
- Inhalation of the Essential Oil of Piper guineense from Cameroon Shows Sedative and Anxiolytic-Like Effects in MiceBiological & Pharmaceutical Bulletin, 2013
- Sedative effect of vapor inhalation of essential oil fromHeracleum afghanicumKitamura seedsJournal of Essential Oil Research, 2012
- Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compoundsJournal of Natural Medicines, 2011
- Antidepressant-like Effect ofl-perillaldehyde in Stress-induced Depression-like Model Mice through Regulation of the Olfactory Nervous SystemEvidence-Based Complementary and Alternative Medicine, 2011
- Sedative effects of vapor inhalation of agarwood oil and spikenard extract and identification of their active componentsJournal of Natural Medicines, 2007