Low Level of Serum Cadmium in Relation to Blood Pressures Among Japanese General Population
- 26 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Biological Trace Element Research
- Vol. 200 (1), 67-75
- https://doi.org/10.1007/s12011-021-02648-8
Abstract
Hypertension (HT) is an important risk factor for mortality and morbidity. Previous studies showed that cadmium (Cd) was associated with increased blood pressures and the prevalence of HT. This study hypothesized that Cd, regardless of its level, may increase blood pressures/HT. The objective of this study was to examine the associations between a low level of serum Cd concentration and blood pressures/HT among a general population in the Iwaki area, Japan. This was a cross-sectional study, conducted in the Aomori prefecture with 1144 volunteers aged over 19 years old, who were participants of the Iwaki health check-up in 2014. The study assessed questionnaire survey, body composition, and serum Cd concentrations. Median serum Cd concentration was 0.06 ng/mL (interquartile range 0.05–0.08 ng/mL) among our study population. Compared to the lowest quintile of serum Cd concentration group, the highest quintile of serum Cd concentration group had 4.9 mmHg higher systolic blood pressure (SBP) (95% confidence interval [CI] 1.53–8.31, p < 0.01) and 2.4 mmHg higher diastolic blood pressure (DBP) (95% CI 0.36–4.34, p < 0.05), compared to the lowest quintile group. Similarly, the highest quintile of serum Cd concentration group had 1.7 times higher prevalence of HT (95% CI 1.10–2.51, p < 0.05) than the lowest quintile group. This study identified that higher serum Cd concentration was significantly, positively, associated with SBP and DBP and HT prevalence. This study provided evidence for the associations between environmental exposure to Cd and blood pressures/HT which should be considered for future preventive measures.Keywords
Funding Information
- Japan Science and Technology Agency (JPMJCE1302)
This publication has 42 references indexed in Scilit:
- The relationship between cadmium in kidney and cadmium in urine and blood in an environmentally exposed populationToxicology and Applied Pharmacology, 2013
- Blood pressure categories and long-term risk of cardiovascular disease according to age group in Japanese men and womenHypertension Research, 2012
- Cadmium in blood and hypertensionScience of The Total Environment, 2008
- Understanding the decline of mean systolic blood pressure in Japan: an analysis of pooled data from the National Nutrition Survey, 1986-2002Bulletin of the World Health Organization, 2008
- Cadmium Exposure and Hypertension in the 1999–2004 National Health and Nutrition Examination Survey (NHANES)Environmental Health Perspectives, 2008
- Monitoring of cadmium toxicity in a Thai population with high-level environmental exposureToxicology Letters, 2007
- Tissue cadmium (Cd) concentrations of people living in a Cd polluted area, JapanBioMetals, 2006
- Cadmium-Induced Effects on Bone in a Population-Based Study of WomenEnvironmental Health Perspectives, 2006
- Vascular calcium channels and high blood pressure: Pathophysiology and therapeutic implicationsVascular Pharmacology, 2006
- Alcohol intake and blood pressureJournal of Hypertension, 1998