Synthesis and systematic review of reported neonatal SARS-CoV-2 infections
Top Cited Papers
Open Access
- 15 October 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Communications
- Vol. 11 (1), 1-10
- https://doi.org/10.1038/s41467-020-18982-9
Abstract
A number of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections have been reported in neonates. Here, we aim to clarify the transmission route, clinical features and outcomes of these infections. We present a meta-analysis of 176 published cases of neonatal SARS-CoV-2 infections that were defined by at least one positive nasopharyngeal swab and/or the presence of specific IgM. We report that 70% and 30% of infections are due to environmental and vertical transmission, respectively. Our analysis shows that 55% of infected neonates developed COVID-19; the most common symptoms were fever (44%), gastrointestinal (36%), respiratory (52%) and neurological manifestations (18%), and lung imaging was abnormal in 64% of cases. A lack of mother–neonate separation from birth is associated with late SARS-CoV-2 infection (OR 4.94 (95% CI: 1.98–13.08), p = 0.0002; adjusted OR 6.6 (95% CI: 2.6–16), p < 0.0001), while breastfeeding is not (OR 0.35 (95% CI: 0.09–1.18), p = 0.10; adjusted OR 2.2 (95% CI: 0.7–6.5), p = 0.148). Our findings add to the literature on neonatal SARS-CoV-2 infections.Keywords
This publication has 107 references indexed in Scilit:
- Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical recordsThe Lancet, 2020
- Potential Maternal and Infant Outcomes from Coronavirus 2019-nCoV (SARS-CoV-2) Infecting Pregnant Women: Lessons from SARS, MERS, and Other Human Coronavirus InfectionsViruses, 2020
- Methodological quality and synthesis of case series and case reportsBMJ Evidence-Based Medicine, 2018
- The Montreux definition of neonatal ARDS: biological and clinical background behind the description of a new entityThe Lancet Respiratory Medicine, 2017
- Epidemiologic Trends in Neonatal Intensive Care, 2007-2012JAMA Pediatrics, 2015
- The CARE guidelines: consensus-based clinical case report guideline developmentJournal of Clinical Epidemiology, 2014
- Neonatal sepsisVirulence, 2013
- GRADE guidelines: 15. Going from evidence to recommendation—determinants of a recommendation's direction and strengthJournal of Clinical Epidemiology, 2013
- Distribution of Angiotensin-(1-7) and ACE2 in Human Placentas of Normal and Pathological PregnanciesPlacenta, 2006
- Meta-analysis of Observational Studies in EpidemiologyA Proposal for ReportingJAMA, 2000