Early Diagnosis of Pancreatic Cancer: The Key for Survival
Open Access
- 24 October 2020
- journal article
- review article
- Published by MDPI AG in Diagnostics
- Vol. 10 (11), 869
- https://doi.org/10.3390/diagnostics10110869
Abstract
Pancreatic cancer (PC) is one of the most aggressive forms of cancer. Negative prognosis is mainly due to the late diagnosis in advanced stages, when the disease is already therapeutically overcome. Studies in recent years have focused on identifying biomarkers that could play a role in early diagnosis, leading to the improvement of morbidity and mortality. Currently, the only biomarker widely used in the diagnosis of PC is carbohydrate antigen 19-9 (CA19.9), which has, however, more of a prognostic role in the follow-up of postoperative recurrence than a diagnostic role. Other biomarkers, recently identified as the methylation status of ADAMTS1 (A disintegrin and metalloproteinase with thrombospondin motifs 1) and BNC1 (zinc finger protein basonuclin-1) in cell-free deoxyribonucleic acid (DNA), may play a role in the early detection of PC. This review focuses on the diagnosis of PC in its early stages.Keywords
This publication has 112 references indexed in Scilit:
- Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinomaBMC Surgery, 2013
- Pancreatic Cancer ScreeningGastroenterology Clinics of North America, 2012
- Genetic susceptibility to pancreatic cancerMolecular Carcinogenesis, 2011
- Stool DNA testing for the detection of pancreatic cancerCancer, 2011
- Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan)Cancer Causes & Control, 2010
- PALB2 mutations in European familial pancreatic cancer familiesClinical Genetics, 2010
- ABO Blood Group, Helicobacter pylori Seropositivity, and Risk of Pancreatic Cancer: A Case-Control StudyJNCI Journal of the National Cancer Institute, 2010
- Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations and risk for pancreatic adenocarcinomaCancer, 2009
- Cigarette Smoking and Pancreatic Cancer: A Pooled Analysis From the Pancreatic Cancer Cohort ConsortiumAmerican Journal of Epidemiology, 2009
- Surgical Management of Solid-Pseudopapillary Neoplasms of the Pancreas (Franz or Hamoudi Tumors): A Large Single-Institutional SeriesJournal of the American College of Surgeons, 2009