Extraovarian Brenner tumor in the uterus: a case report and review of literature
Open Access
- 12 March 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Diagnostic Pathology
- Vol. 15 (1), 1-8
- https://doi.org/10.1186/s13000-019-0906-1
Abstract
Extraovarian Brenner tumors (EOBTs) are extremely rare and can be observed incidentally in both female and male patients, raising concerns regarding the origin of Brenner tumors. A 53-year-old postmenopausal woman presented with a nodular lesion in the left side of the corpus uteri, which was found at a routine health check. Macroscopically, the lesion appeared as a solid nodule with a yellowish-gray cut surface, approximately 6 cm in greatest diameter. Microscopically, the lesion consisted of well-defined epithelial nests and spindled stromal cells. Parenchymal cells expressed CK7, GATA3, CK5/6, 34βE12, and p63. A single layer of cavity-lined cells with umbrella-like shape showed apical Uroplakin III positivity. Stromal cells were positive for SMA, ER, and PR. The final diagnosis was EOBT and the patient was followed for 2 months with no recurrence. We report here the third case of EOBTs in the uterus. The combination of morphologic and immunohistochemical results supported the involvement of urothelial metaplasia in the development of EOBTs. The similarities between EOBTs and Walthard nests made Müllerian epithelium an attractive candidate as the cellular origin. Changes of tissue structure or sex hormones imbalance may lead to the translocation of Müllerian remnants to distant organs, explaining the pathogenesis of EOBTs.Keywords
Funding Information
- The National Natural Science Foundation of China (81770624 and 81860490)
- Foundation for Distinguished Young Talents in Higher Education of Guangdong (20192BCB23025)
- Foundation of Health and Family Planning Commission of Jiangxi Province (20171098)
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