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Mitochondrial Damage and Drp1 Overexpression in Rifampicin- and Isoniazid-induced Liver Injury Cell Model

Fangfang Li, Juan Zhou, Yi Li, Kewei Sun, Jun Chen
Journal of Clinical and Translational Hepatology , Volume 7, pp 40-45; doi:10.14218/JCTH.2018.00052

Abstract: Background and Aims: Rifampicin (RFP) and isoniazid (INH) are widely used as anti-tuberculosis agents. However, the mechanisms underlying the involvement of reactive oxygen species and mitochondria in RFP- and INH-related hepatotoxicity have not been established yet. This study aimed to observe the intracellular mechanisms leading to mitochondrial dysfunction and morphological changes in RFP- and INH-induced hepatocyte injury.
Keywords: mitochondrial dysfunction / mitochondrial fission / drp1 / Anti-tuberculosis Drug-induced Liver Injury

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