Mitochondrial Damage and Drp1 Overexpression in Rifampicin- and Isoniazid-induced Liver Injury Cell Model
Open Access
- 15 March 2019
- journal article
- research article
- Published by Xia & He Publishing in Journal of Clinical and Translational Hepatology
- Vol. 7 (X), 1-6
- https://doi.org/10.14218/jcth.2018.00052
Abstract
Background and Aims: Rifampicin (RFP) and isoniazid (INH) are widely used as anti-tuberculosis agents. However, the mechanisms underlying the involvement of reactive oxygen species and mitochondria in RFP- and INH-related hepatotoxicity have not been established yet. This study aimed to observe the intracellular mechanisms leading to mitochondrial dysfunction and morphological changes in RFP- and INH-induced hepatocyte injury.Keywords
This publication has 22 references indexed in Scilit:
- Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytesRedox Biology, 2014
- Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescenceAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2013
- Mitochondria are targets for the antituberculosis drug rifampicin in cultured epithelial cellsBiochemistry (Moscow), 2013
- Hepatocyte Growth Factor Protects Against Isoniazid/Rifampicin-Induced Oxidative Liver DamageToxicological Sciences, 2013
- Mitochondrial pharmacologyTrends in Pharmacological Sciences, 2012
- Inhibition of Drp1 provides neuroprotection in vitro and in vivoCell Death & Differentiation, 2012
- Modulatory activity of antioxidants against the toxicity of Rifampicin in vivo.Revista do Instituto de Medicina Tropical de São Paulo, 2010
- Antituberculosis therapy-induced acute liver failure: Magnitude, profile, prognosis, and predictors of outcomeJournal of Hepatology, 2010
- Mitochondrial fragmentation in neurodegenerationNature Reviews Neuroscience, 2008
- Mitochondrial oxidative stress and permeability transition in Isoniazid and Rifampicin induced liver injury in miceJournal of Hepatology, 2006