Potential Misdiagnosis between COVID-19 and Dengue Infection Using Rapid Serological Test
Open Access
- 6 June 2021
- journal article
- research article
- Published by MDPI AG in Infectious Disease Reports
- Vol. 13 (2), 540-551
- https://doi.org/10.3390/idr13020050
Abstract
The coronavirus disease 2019 (COVID-19) pandemic that has a significant rapid transmission is an international public health concern. Several dengue-endemic countries reported similar clinical and laboratory features between COVID-19 and dengue in the early incubation period, and thus discerning the infection is difficult. As a dengue-endemic country, Indonesia also poses the same challenge during the COVID-19 outbreak. This current study analyzed the IgG and IgM profiles from COVID-19 patients by using a serological SARS-CoV-2 and dengue rapid test. In addition, 38 sera from healthy individuals (pre-COVID-19 date) were analyzed using a dengue rapid test. Among 120 samples, 4 samples indicated dengue IgG positive. However, IgM, NS1, and RT-PCR analyses showed negative results. Interestingly, regarding seropositivity of NS1 and DENV IgG from healthy individuals (pre COVID-19 infection), two samples were positive DENV IgG, while one of them was positive NS1. This suggested that in the dengue-endemic area, many people have already experienced dengue and have immunity against dengue virus. There is also the possibility of antibody cross-reactivity between COVID-19 and dengue infection. This also emphasizes the high demand for a rapid method with high sensitivity and specificity that can distinguish between SARS-CoV-2 and dengue.Funding Information
- Universitas Airlangga (1093/UN3.14/PT/2020)
This publication has 27 references indexed in Scilit:
- The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and ApplicationAnnals of Internal Medicine, 2020
- When Can One Vaccinate with a Live Vaccine after Wild-Type Dengue Infection?Vaccines, 2020
- Covert COVID-19 and false-positive dengue serology in SingaporeThe Lancet Infectious Diseases, 2020
- COVID-19 in medical personnel: observation from ThailandJournal of Hospital Infection, 2020
- Detection of multiple viral sequences in the respiratory tract samples of suspected Middle East respiratory syndrome coronavirus patients in Jakarta, Indonesia 2015–2016International Journal of Infectious Diseases, 2019
- Dengue Infection Spectrum in Guangzhou: A Cross-Sectional Seroepidemiology Study among Community Residents between 2013 and 2015International Journal of Environmental Research and Public Health, 2018
- Detection and Serotyping of Dengue Viruses in Aedes aegypti and Aedes albopictus (Diptera: Culicidae) Collected in Surabaya, Indonesia from 2008 to 2015Japanese Journal of Infectious Diseases, 2018
- Clinical and virological characteristics of dengue in Surabaya, IndonesiaPLOS ONE, 2017
- Seroprevalence of Asymptomatic Dengue Virus Infection and Its Antibodies Among Healthy/Eligible Saudi Blood Donors: Findings From Holy Makkah CityVirology: Research and Treatment, 2017
- Divergence of the dengue virus type 2 Cosmopolitan genotype associated with two predominant serotype shifts between 1 and 2 in Surabaya, Indonesia, 2008–2014Infection, Genetics and Evolution, 2016