Abstract:To the Editor: With respect to the review article on chronic urticaria by Lang (Sept. 1 issue),¹ angioedema may be of special interest. Bradykinin-mediated angioedema was not addressed in the review. This rare chronic hereditary urticaria mediated by bradykinin may be life-threatening, and treatments for this condition have been developed.² Clinicians may also see angiotensin-converting–enzyme (ACE) inhibitor–induced angioedema that does not respond to treatment with antihistamines and glucocorticoids. To the Editor: In the review article on chronic urticaria, Figure 3 describes stepped care. The author states that the information in this figure was synthesized from recommendations based on clinical guidelines. . . .