A Mini Review on the Pathogenesis, Diagnosis and Treatment Options for COVID-19
- 1 March 2022
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Infectious Disorders - Drug Targets
- Vol. 22 (2), 13-21
- https://doi.org/10.2174/1871526521666210301142223
Abstract
: Coronavirus disease 2019 (COVID-19) is a serious viral disease caused by SARS-CoV-2, associated with high morbidity and mortality, and represents a significant public health crisis worldwide. Despite recent efforts for developing novel antiviral agents, no specific drugs are approved for the management and treatment of COVID-19. The immune responses to viral infection followed by cytokine storm and acute respiratory distress syndrome are serious issues that may cause death in patients with severe COVID-19. Therefore, developing a novel therapeutic strategy for the management of COVID-19 is urgently needed to control the virus spread and to improve the patient survival rate and clinical outcomes. In this mini-review, we summarize the symptoms, pathogenesis, and therapeutic approaches currently being used to manage the spread of SARS-CoV-2.Keywords
Funding Information
- Mashhad University of Medical Sciences (MUMS-991114)
This publication has 61 references indexed in Scilit:
- Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation studyThe Lancet Infectious Diseases, 2018
- Host Factors in Coronavirus ReplicationPublished by Springer Science and Business Media LLC ,2017
- Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathologySeminars in Immunopathology, 2017
- Epidemiology, Genetic Recombination, and Pathogenesis of CoronavirusesTrends in Microbiology, 2016
- Receptor Recognition Mechanisms of Coronaviruses: a Decade of Structural StudiesJournal of Virology, 2015
- Coronaviruses: An Overview of Their Replication and PathogenesisPublished by Springer Science and Business Media LLC ,2015
- Angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis prevents lipopolysaccharide–induced apoptosis of pulmonary microvascular endothelial cells by inhibiting JNK/NF–κB pathwaysScientific Reports, 2015
- Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathyLaboratory Investigation, 2012
- A serological survey on neutralizing antibody titer of SARS convalescent seraJournal of Medical Virology, 2005
- Oxidative stress is a critical mediator of the angiotensin II signal in human neutrophils: involvement of mitogen-activated protein kinase, calcineurin, and the transcription factor NF-κBBlood, 2003