Liver stiffness does not affect ultrasound‐guided attenuation coefficient measurement in the evaluation of hepatic steatosis
- 29 October 2019
- journal article
- research article
- Published by Wiley in Hepatology Research
- Vol. 50 (2), 190-198
- https://doi.org/10.1111/hepr.13442
Abstract
Aims Recently, a new method has been developed to diagnose hepatic steatosis with attenuation coefficients based on the ultrasound‐guided attenuation parameter (UGAP). We investigated whether fibrosis identified by hepatic stiffness measurements based on magnetic resonance elastography (MRE) affects attenuation coefficient measurement using UGAP for the evaluation of hepatic steatosis. Methods A total of 608 patients with chronic liver disease were analyzed. Correlations between magnetic resonance imaging–determined proton density fat fraction (PDFF) or MRE value and attenuation coefficients were evaluated. In addition, the interaction between hepatic fibrosis and attenuation coefficient was analyzed. Results The correlation coefficient (r) between PDFF values and attenuation coefficient values was 0.724, indicating a strong relationship. Conversely, the r between MRE values and attenuation coefficient values was ‐0.187, indicating almost no relationship. In the multiple regression assessment of the effect of PDFF and MRE on attenuation coefficient based on UGAP, the p values for PDFF, MRE, and PDFF×MRE were <0.001, 0.277, and 0.903, respectively. In patients with non‐alcoholic fatty liver disease (n=169), the r between PDFF values and attenuation coefficient values was 0.695, indicating a moderate relationship. Conversely, the r between MRE values and attenuation coefficient values was ‐0.068, indicating almost no relationship. In the multiple regression assessment of the effect of PDFF and MRE on attenuation coefficient based on UGAP, the p values for PDFF, MRE, and PDFF×MRE were <0.001, 0.948, and 0.706, respectively. Conclusion UGAP‐determined attenuation coefficient was weakly affected by liver stiffness, an indicator of hepatic fibrosis.Keywords
This publication has 36 references indexed in Scilit:
- Investigation of the freely available easy-to-use software ‘EZR’ for medical statisticsBone Marrow Transplantation, 2012
- Correlation between liver histology and novel magnetic resonance imaging in adult patients with non‐alcoholic fatty liver disease – MRI accurately quantifies hepatic steatosis in NAFLDAlimentary Pharmacology & Therapeutics, 2012
- Diagnosis of liver fibrosis and cirrhosis using liver stiffness measurement: Comparison between M and XL probe of FibroScan®Journal of Hepatology, 2012
- Early Detection of Nonalcoholic Steatohepatitis in Patients with Nonalcoholic Fatty Liver Disease by Using MR ElastographyRadiology, 2011
- Controlled Attenuation Parameter (CAP): A Novel VCTE™ Guided Ultrasonic Attenuation Measurement for the Evaluation of Hepatic Steatosis: Preliminary Study and Validation in a Cohort of Patients with Chronic Liver Disease from Various CausesJapanese Journal of Clinical Oncology, 2010
- Quantification of hepatic steatosis with MRI: The effects of accurate fat spectral modelingJournal of Magnetic Resonance Imaging, 2009
- Liver biopsyHepatology, 2008
- Steatosis affects chronic hepatitis C progression in a genotype specific wayGut, 2004
- Lipoprotein Metabolism in Obesity and Diabetes: Insights from Stable Isotope Kinetic Studies in HumansNutrition Reviews, 2003
- Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesityHepatology, 2001