The current role of surgery and SBRT in early stage of small cell lung cancer
Open Access
- 17 February 2021
- Vol. 7 (1), 34-48
Abstract
Early stage small cell lung cancer (T1-2N0M0SCLC) represents 7% of all SCLC. The standard treatment in patients with intrathoracic SCLC disease is the use of concurrent chemoradiotherapy (CRT). Nowadays, the recommended management of this highly selected group is surgical resection due to favorable survival outcomes. For medically inoperable patients or those who refuse surgery, there is an increasing interest in evaluating the role of Stereotactic Body Radiotherapy (SBRT) for T1-2N0SCLC, transferring the favorable experience obtained on inoperable NSCLC (Non-Small-cell Lung Cancer). In the era of multimodality treatment, adjuvant systemic therapy plays an important role even in the management of early SCLC, increasing the disease-free survival (DFS) and Overall Survival (OS). The benefit of Prophylactic Cranial Irradiation (PCI), that currently has a Category I recommendation for localized stage SLCL, remains controversial in this selected subgroup of patients due to the lower risk of brain metastasis. This review summarizes the most relevant data on the local management of T1-2N0M0SCLC (surgery and radiotherapy), and evaluates the relevance of adjuvant treatment. Provides a critical evaluation of best current clinical management options for T1-2N0M0 SCLC.Keywords
This publication has 99 references indexed in Scilit:
- Stereotactic Body Radiation Therapy for Stage I Non-small-cell Lung Cancer: A Historical Overview of Clinical StudiesJapanese Journal of Clinical Oncology, 2013
- Surgical Resection for Small Cell Lung Cancer: Pneumonectomy versus LobectomyISRN Surgery, 2012
- Surgical Outcomes in Small Cell Lung CancerThe Korean Journal of Thoracic and Cardiovascular Surgery, 2012
- Patterns of recurrence and outcome in patients with surgically resected small cell lung cancerInternational Journal of Clinical Oncology, 2011
- The Applicability of the Proposed IASLC Staging Revisions to Small Cell Lung Cancer (SCLC) with Comparison to the Current UICC 6th TNM EditionJournal of Thoracic Oncology, 2009
- The Role of Surgery in the Treatment of Limited Disease Small Cell Lung Cancer: Time to ReevaluateJournal of Thoracic Oncology, 2008
- Changing Epidemiology of Small-Cell Lung Cancer in the United States Over the Last 30 Years: Analysis of the Surveillance, Epidemiologic, and End Results DatabaseJournal of Clinical Oncology, 2006
- Results of surgery in small cell carcinoma of the lungLung Cancer, 2006
- Small cell lung cancer in Norway. Should more patients have been offered surgical therapy?European Journal of Cardio-Thoracic Surgery, 2004
- Patterns of failure in small cell carcinoma of the lungCancer, 1982