Etiologies of Rheumatoid Arthritis: Update on Mucosal, Genetic, and Cellular Pathogenesis
- 1 March 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Current Rheumatology Reports
- Vol. 23 (4), 1-10
- https://doi.org/10.1007/s11926-021-00993-0
Abstract
Purpose of Review Over the last few years, the scientific community has made significant progress in understanding the etiology of rheumatoid arthritis (RA). In this review, we summarize those key findings and trends. Recent Findings New data strongly implicates respiratory exposures, obesity, diet and microbiome, genetics, and their interactions in the etiology of RA. Furthermore, anti-posttranslationally modified protein antibodies (AMPAs) and abnormal glycosylation may be additional biomarkers for RA. Finally, functional genomics techniques implicate loss of certain macrophage populations and proliferation of synovial fibroblasts in RA. Summary These findings support the notion that RA originates at mucosal sites, augmented by genetic predisposition, and mediated by certain cell types including macrophages and fibroblasts. Weight loss, physical activity, and diet are additional modifiable factors beyond smoking cessation that can reduce risk of RA. Future epidemiologic and translational studies leveraging multi-omics approaches will help map the precise sequence of events in RA pathogenesis.Keywords
This publication has 98 references indexed in Scilit:
- Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritiseLife, 2013
- On the Origin of Rheumatoid Arthritis: The Impact of Environment and Genes—A Population Based Twin StudyPLOS ONE, 2013
- Bayesian inference analyses of the polygenic architecture of rheumatoid arthritisNature Genetics, 2012
- EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid ArthritisAnnals Of The Rheumatic Diseases, 2012
- A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullinationArthritis & Rheumatism, 2005
- A gene–environment interaction between smoking and shared epitope genes in HLA–DR provides a high risk of seropositive rheumatoid arthritisArthritis & Rheumatism, 2004
- Oral contraceptives, cigarette smoking and other factors in relation to arthritisContraception, 1987
- Silica exposure and rheumatoid arthritis: a follow up study of granite workers 1940-81.BMJ, 1987
- Evidence for an association between rheumatoid arthritis and autoimmune endocrine disease.Annals Of The Rheumatic Diseases, 1983
- Certain Unusual Radiological Appearances in the Chest of Coal-miners Suffering from Rheumatoid ArthritisThorax, 1953