Microbial-derived antigens and metabolites in spondyloarthritis
- 10 February 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Seminars in Immunopathology
- Vol. 43 (2), 163-172
- https://doi.org/10.1007/s00281-021-00844-1
Abstract
Spondyloarthritis (SpA) is a group of chronic, immune-mediated, inflammatory diseases affecting the bone, synovium, and enthesis. Microbiome, the community of microorganisms that has co-evolved with human hosts, plays a pivotal role in human health and disease. This invisible “essential organ” supplies the host with a myriad of chemicals and molecules. In turn, microbial metabolites can serve as messengers for microbes to communicate with each other and in the cross-talk with host cells. Gut dysbiosis in SpA is associated with altered microbial metabolites, and an accumulated body of research has contributed to the understanding that changes in intestinal microbiota can modulate disease pathogenesis. We review the novel findings from human and animal studies to provide an overview of the contribution of individual microbial metabolites and antigens to SpA.Keywords
Funding Information
- National Institutes of Health (R01HL125816, R01AR070131, R01AR073851)
- The Judith and Stewart Colton Center for Autoimmunity
- National Psoriasis Foundation (21-A0-00-1003713, 21-A0-00-1003713)
- Drs. Martin and Drothy Spatz Foundation
- LEO Foundation (LF-OC-20-000351)
- The Irma T. Hirschl and Monique Weill-Caulier Trust
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR074500)
- Riley Family Foundation
- Beatrice Snyder Foundation
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