Antioxidant and Immunopotentiating Effects of Cordyceps Mycelium Extract, Chicken Essence, and Their Combination in Experimental Models
Open Access
- 1 January 2021
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in Chinese Medicine
- Vol. 12 (01), 1-9
- https://doi.org/10.4236/cm.2021.121001
Abstract
Cordyceps mycelium extract (Cs-4), Chicken Essence (CE), and their combination were investigated for antioxidant and immunomodulatory activities in mouse models. Long-term treatment with Cs-4 or CE at equivalent human doses improved antioxidant status in various tissues, as evidenced by the enhancement of mitochondrial glutathione redox status in the brain, liver, heart, and kidney of mice. Cs-4 or CE treatment also produced an immunomodulatory action, as indicated by the potentiation of Concanavalin A-/lipopolysaccharide-induced proliferation of mouse splenocytes ex vivo. While doubling of the equivalent human doses of Cs-4 and CE did not further enhance their antioxidant or immunopotentiating effects, the combined treatment with Cs-4 and CE at their respective equivalent human doses produced an additive effect, with the extents of stimulation being larger than those produced by Cs-4 or CE alone. The results have demonstrated for the first time that the combined use of Cs-4 and CE can produce an additive effect on both antioxidation and immunopotentiation that cannot otherwise be achieved by increasing the equivalent human doses of Cs-4 or CE alone.Keywords
This publication has 17 references indexed in Scilit:
- CHAPTER 11. Antioxidant Activity of Imidazole DipeptidesPublished by Royal Society of Chemistry (RSC) ,2015
- The Effect of Chicken Extract on Mood, Cognition and Heart Rate VariabilityNutrients, 2015
- Chicken Essence Improves Exercise Performance and Ameliorates Physical FatigueNutrients, 2014
- Immune SystemPublished by Elsevier BV ,2014
- Bioactivities of Chicken EssenceJournal of Food Science, 2012
- Long-Term Treatment with a Compound Polysaccharide-Based Health Product (Infinitus Polysac Plus) Enhances Innate and Adaptive Immunity in MiceChinese Medicine, 2011
- Long-Term Treatment with Shengmai San-Derived Herbal Supplement (Wei Kang Su) Enhances Antioxidant Response in Various Tissues of Rats with Protection Against Carbon Tetrachloride HepatotoxicityJournal of Medicinal Food, 2010
- Reactive oxygen species, cellular redox systems, and apoptosisFree Radical Biology & Medicine, 2010
- Long-Term Treatment with a Yang-Invigorating Chinese Herbal Formula Produces Generalized Tissue Protection Against Oxidative Damage in RatsRejuvenation Research, 2008
- Effects of Chicken Essence Tablets on Resting Metabolic RateBioscience, Biotechnology, and Biochemistry, 2001