The gut microbiome and potential implications for early-onset colorectal cancer
- 1 September 2020
- journal article
- review article
- Published by Taylor & Francis Ltd in Colorectal Cancer
- Vol. 9 (3)
- https://doi.org/10.2217/crc-2020-0007
Abstract
Recently, there has been an unexpected trend toward increased incidence of colorectal cancer in younger individuals, particularly distal colon and rectal cancer in those under age 50. There is evidence to suggest that the human gut microbiome may play a role in carcinogenesis. The microbiome is dynamic and varies with age, geography, ethnicity and diet. Certain bacteria such asFusobacterium nucleatumhave been implicated in the development of colorectal and other gastrointestinal cancers. Recent data suggest that bacteria can alter the inflammatory and immune environment, influencing carcinogenesis, lack of treatment response and prognosis. Studies to date focus on older patients. Because the microbiome varies with age, it could be a potential explanation for the rise in early-onset colorectal cancer.Keywords
This publication has 106 references indexed in Scilit:
- Intestinal Inflammation Targets Cancer-Inducing Activity of the MicrobiotaScience, 2012
- Genomic analysis identifies association of Fusobacterium with colorectal carcinomaGenome Research, 2011
- Fusobacterium nucleatum infection is prevalent in human colorectal carcinomaGenome Research, 2011
- The human commensal Bacteroides fragilis binds intestinal mucinAnaerobe, 2011
- The microbiome and rheumatoid arthritisNature Reviews Rheumatology, 2011
- Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural AfricaProceedings of the National Academy of Sciences of the United States of America, 2010
- Succession of microbial consortia in the developing infant gut microbiomeProceedings of the National Academy of Sciences of the United States of America, 2010
- The NIH Human Microbiome ProjectGenome Research, 2009
- A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responsesNature Medicine, 2009
- Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adultsEnvironmental Microbiology, 2009