Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Top Cited Papers
Open Access
- 23 October 2020
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 370 (6515), 423-+
- https://doi.org/10.1126/science.abd4585
Abstract
Interindividual clinical variability in the course of SARS-CoV-2 infection is immense. We report that at least 101 of 987 patients with life-threatening COVID-19 pneumonia had neutralizing IgG auto-Abs against IFN-ω (13 patients), the 13 types of IFN-α (36), or both (52), at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1,227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 were men. A B cell auto-immune phenocopy of inborn errors of type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.This publication has 48 references indexed in Scilit:
- Evolutionary genetic dissection of human interferonsThe Journal of Experimental Medicine, 2011
- Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrationsNature Biotechnology, 2010
- Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type IThe Journal of Experimental Medicine, 2010
- Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokinesThe Journal of Experimental Medicine, 2010
- phyloXML: XML for evolutionary biology and comparative genomicsBMC Bioinformatics, 2009
- Evolution of the interferon alpha gene family in eutherian mammalsGene, 2007
- Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1PLoS Medicine, 2006
- MAFFT version 5: improvement in accuracy of multiple sequence alignmentNucleic Acids Research, 2005
- STATs and Gene RegulationScience, 1997
- The rapid generation of mutation data matrices from protein sequencesBioinformatics, 1992