Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations
Open Access
- 2 July 2021
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 81 (17), 4499-4513
- https://doi.org/10.1158/0008-5472.can-20-4016
Abstract
This study has developed a novel NMD reporter system and identified a potential therapeutic approach of targeting the NMD pathway to treat cancer with spliceosome gene mutations.Keywords
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Funding Information
- NCI (P01 CA101937)
- NIH (R01GM098535)
- Siteman Investment Program Awards (4036, 5124)
- Washington University (4036,5124)
- Developmental Research Program (DRP-1901)
- NCI (P50CA171963)
- Edward P. Evans Foundation
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