Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms
Open Access
- 23 July 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 10 (1), 1-13
- https://doi.org/10.1038/s41598-020-69277-4
Abstract
Zinc is a biologically essential element and involved in a wide range of cellular processes. Here, we investigated the associations of zinc levels in hair with brain activity during the n-back working memory task using functional magnetic resonance imaging, fractional anisotropy (FA) of diffusion tensor imaging, and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that greater hair zinc levels were associated with lower brain activity during working memory in extensive areas in the default mode network (i.e., greater task-induced deactivation) as well as greater FA in white matter areas near the hippocampus and posterior limbs of the internal capsule. These findings advance previous non-neuroimaging findings of zinc's associations with excitability, excitability-associated disorders, and myelination.Funding Information
- The Ministry of Education, Culture, Sports, Science, and Technology (A Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306) and a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012), A Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306) and a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012), A Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306) and a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012))
This publication has 77 references indexed in Scilit:
- Effects of working memory training on functional connectivity and cerebral blood flow during restCortex, 2013
- Neural Correlates of Working Memory Performance in Primary InsomniaSleep, 2013
- Spurious but systematic correlations in functional connectivity MRI networks arise from subject motionNeuroImage, 2012
- Cortical parvalbumin interneurons and cognitive dysfunction in schizophreniaTrends in Neurosciences, 2012
- Infantile zinc deficiency: Association with autism spectrum disordersScientific Reports, 2011
- Regional gray matter volume of dopaminergic system associate with creativity: Evidence from voxel-based morphometryNeuroImage, 2010
- Metallomics study using hair mineral analysis and multiple logistic regression analysis: relationship between cancer and mineralsEnvironmental Health and Preventive Medicine, 2009
- Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophreniaProceedings of the National Academy of Sciences of the United States of America, 2009
- Detecting and adjusting for artifacts in fMRI time series dataNeuroImage, 2005
- Specificity of zinc binding to myelin basic proteinNeurochemical Research, 1995