Tactics of chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the pharynx with index of metastatic regional lymph nodes stage N3
Open Access
- 8 August 2021
- journal article
- Published by Publishing House ABV Press in Head and Neck Tumors (HNT)
- Vol. 11 (2), 25-30
- https://doi.org/10.17650/2222-1468-2021-11-2-25-30
Abstract
During 1996–2015 years, 53 patients with stage locally-advanced squamous cell carcinoma of the pharynx with stage N3 were treated in N. N. Blokhin National Research Center of Oncology. Depending on the treatment method, patients were divided into 2 groups: concurrent (n = 26) and induction (n = 27) chemoradiotherapy. Concurrent chemoradiotherapy (option 1) was given using: cisplatin 100 mg/m2 – every 3 weeks, or carboplatin 1.5 AUC weekly, or cisplatin 100 mg/m2 with 5-fluorouracil 1000 mg/m2 every 24 hours, in continuous infusion for 96 hours (PF). Induction chemotherapy (option 2) was performed in 2 modes: TPF (docetaxel, cisplatin, 5-fluorouracil) or PF (cisplatin, 5-fluorouracil). Radiation therapy was performed on a linear accelerator for 2 Gy daily up to SD 68–70 Gy for the primary tumor and 66 Gy for the affected lymph nodes. According to the results of our retrospective study, the 3 year overall and relapse-free survival rate depending on the chemoradiotherapy option was 37 and 32 % (option 1), 62 and 56 % (option 2). A promising option for chemoradiotherapy of locally advanced squamous cell carcinoma of the pharynx is induction chemoradiotherapy.Keywords
This publication has 8 references indexed in Scilit:
- Taxane-Cisplatin-Fluorouracil As Induction Chemotherapy in Locally Advanced Head and Neck Cancers: An Individual Patient Data Meta-Analysis of the Meta-Analysis of Chemotherapy in Head and Neck Cancer GroupJournal of Clinical Oncology, 2013
- Induction chemotherapy with cisplatin and fluorouracil alone or in combination with docetaxel in locally advanced squamous-cell cancer of the head and neck: long-term results of the TAX 324 randomised phase 3 trialThe Lancet Oncology, 2011
- Advances in radiotherapy of head and neck cancersCurrent Opinion in Oncology, 2010
- Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patientsRadiotherapy and Oncology, 2009
- Outcomes of Patients with N3 Neck Nodes Treated with ChemoradiationThe Laryngoscope, 2008
- Cisplatin, Fluorouracil, and Docetaxel in Unresectable Head and Neck CancerThe New England Journal of Medicine, 2007
- Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual dataThe Lancet, 2000
- Induction Chemotherapy plus Radiation Compared with Surgery plus Radiation in Patients with Advanced Laryngeal CancerThe New England Journal of Medicine, 1991