IL-17-Mediated Inflammation Promotes Cigarette Smoke-Induced Genomic Instability
Open Access
- 12 May 2021
- Vol. 10 (5), 1173
- https://doi.org/10.3390/cells10051173
Abstract
(1) Background: Chronic inflammation has been regarded as a risk factor for the onset and progression of human cancer, but the critical molecular mechanisms underlying this pathological process have yet to be elucidated. (2) Methods: In this study, we investigated whether interleukin (IL)-17-mediated inflammation was involved in cigarette smoke-induced genomic instability. (3) Results: Higher levels of both IL-17 and the DNA damage response (DDR) were found in the lung tissues of smokers than in those of non-smokers. Similarly, elevated levels of IL-17 and the DDR were observed in mice after cigarette smoke exposure, and a positive correlation was observed between IL-17 expression and the DDR. In line with these observations, the DDR in the mouse lung was diminished in IL-17 KO when exposed to cigarette smoke. Besides this, the treatment of human bronchial epithelium cells with IL-17 led to increased levels of the DDR and chromosome breakage. (4) Conclusions: These results suggest that cigarette smoke induces genomic instability at least partially through IL-17-mediated inflammation, implying that IL-17 could play an important role in the development of lung cancer.Funding Information
- the Key Laboratory of Respiratory Disease of Zhejiang Province (NA, 2011R50016, NA, 2019KY156, 2016A610193, 2018A610269)
- The National Natural Science Foundation of China (81700023, 81700025, 81422031, 31370901)
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