Atmospheric Pressure Drift Tube Ion Mobility Spectrometry Coupled with Two-Dimensional Tandem Mass Spectrometry
- 7 July 2021
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Society for Mass Spectrometry
- Vol. 32 (8), 2105-2109
- https://doi.org/10.1021/jasms.1c00180
Abstract
Atmospheric pressure drift tube ion mobility was coupled with two-dimensional tandem mass spectrometry (2D MS/MS) in a linear ion trap to simultaneously collect ion mobility and the entire MS/MS data domain. Utilizing ion intensities from precursor ion and neutral loss scan lines, ion mobility spectra of multiple compounds with particular functional groups were acquired in a single experiment. Functional group-specific ion mobility spectra were demonstrated for a standard mixture of lipids. Additionally, ion mobility was used to separate isobaric ions prior to 2D MS/MS. The combination of these two methods offers improvements for the analysis of complex mixtures.Keywords
Funding Information
- U.S. Department of Homeland Security (18200011)
This publication has 38 references indexed in Scilit:
- Collision cross sections obtained with ion mobility mass spectrometry as new descriptor to predict blood-brain barrier permeation by drugsScientific Reports, 2019
- Ion mobility spectrometry and the omics: Distinguishing isomers, molecular classes and contaminant ions in complex samplesTrAC Trends in Analytical Chemistry, 2019
- Review on Ion Mobility Spectrometry. Part 1: current instrumentationThe Analyst, 2014
- Can ion mobility mass spectrometry and density functional theory help elucidate protonation sites in 'small' molecules?Rapid Communications in Mass Spectrometry, 2013
- Ion mobility spectrometry‐mass spectrometry (IMS‐MS) of small molecules: Separating and assigning structures to ionsMass Spectrometry Reviews, 2012
- Biomolecule Analysis by Ion Mobility SpectrometryAnnual Review of Analytical Chemistry, 2008
- Ion mobility–mass spectrometryJournal of Mass Spectrometry, 2008
- Gas-Phase Chiral Separations by Ion Mobility SpectrometryAnalytical Chemistry, 2006
- Mass Analysis of Mobility-Selected Ion Populations Using Dual Gate, Ion Mobility, Quadrupole Ion Trap Mass SpectrometryAnalytical Chemistry, 2005
- Ion Mobility Measurements and their Applications to Clusters and BiomoleculesJournal of Mass Spectrometry, 1997