Bibliometric Analysis of ATAC-Seq and Its Use in Cancer Biology via Nucleic Acid Detection
Open Access
- 3 November 2020
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Medicine
Abstract
Assay for transposase-accessible chromatin using sequencing (ATAC-seq) is associated with significant progress in biological research and has attracted increasing attention. However, the impact of ATAC-seq on cancer biology has not been objectively analyzed. We categorized 440 ATAC-seq publications according to the publication date, type, field, and country. R 3.6.2 was used to analyze the distribution of research fields. VOSviewer was used for country co-authorship and author co-authorship analyses, and GraphPad Prism 8 was used for correlation analyses of the factors that may affect the number of articles published in different countries. We found that ATAC-seq plays roles in carcinogenesis, anticancer immunity, targeted therapy, and metastasis risk predictions and is most frequently used in studies of leukemia among all types of cancer. We found a significantly strong correlation between the top 10 countries in terms of the number of publications and the gross expenditure on research and development (R&D), the number of universities, and the number of researchers. At present, ATAC-seq technology is undergoing a period of rapid development, making it inseparable from the emphasis and investment in scientific research by many countries. Collectively, ATAC-seq has advantages in the study of the cancer mechanisms because it can detect nucleic acids and thus has good application prospects in the field of cancer, especially in leukemia studies. As a country's economic strength increases and the emphasis on scientific research deepens, ATAC-seq will definitely play a more significant role in the field of cancer biology.Funding Information
- National Natural Science Foundation of China (no.81201434)
- Natural Science Foundation of Guangdong Province (no. S2012040007947)
This publication has 45 references indexed in Scilit:
- Global Cancer Incidence and Mortality Rates and Trends—An UpdateCancer Epidemiology, Biomarkers & Prevention, 2016
- Fine-mapping cellular QTLs with RASQUAL and ATAC-seqNature Genetics, 2015
- Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor DifferentiationCell Stem Cell, 2015
- Individuality and Variation of Personal Regulomes in Primary Human T CellsCell Systems, 2015
- ATAC‐seq: A Method for Assaying Chromatin Accessibility Genome‐WideCurrent Protocols in Molecular Biology, 2015
- Tumor metastasis: moving new biological insights into the clinicNature Medicine, 2013
- Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome positionNature Methods, 2013
- Pathogenesis and treatment of leukemia: an Asian perspectiveEmerging Therapeutic Targets, 2012
- Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknessesThe FASEB Journal, 2007
- Searching for intellectual turning points: Progressive knowledge domain visualizationProceedings of the National Academy of Sciences of the United States of America, 2004