Cytotoxic T-lymphocyte Antigen-4 (CTLA-4) Gene Polymorphism (rs3087243) Is Related to Risk and Survival in Patients With Colorectal Cancer
- 23 February 2021
- journal article
- research article
- Published by Anticancer Research USA Inc. in In Vivo
- Vol. 35 (2), 969-975
- https://doi.org/10.21873/invivo.12339
Abstract
Background/Aim: Cytotoxic T-lymphocyte antigen-4 (CTLA-4), transiently expressed on T cells, plays a pivotal role in the negative feedback regulation of T-cell activation and proliferation. The aim of the present study was to examine the influence of CTLA-4 gene polymorphism rs3087243 on CRC susceptibility and long-term survival in Swedish patients with CRC. Patients and Methods: Genotypes of 491 patients and 433 healthy controls were determined, using TaqMan single nucleotide polymorphism (SNP) assays based on polymerase chain reaction. Results: Patients carrying allele A were found to be at a higher risk of CRC and this allele was found to be more common in patients with disseminated disease compared to localized disease in the right colon. Kaplan-Meier analysis of cancer-specific survival showed that carriers of allele A had the highest risk of CRC-related death. Conclusion: The SNP rs3087243 of the CTLA-4 gene was associated with CRC risk and, therefore, it could be a prognostic marker for Swedish patients with CRC.Keywords
This publication has 37 references indexed in Scilit:
- Prognostic biomarkers in colorectal cancer: where do we stand?Virchows Archiv A Pathological Anatomy and Histopathology, 2014
- Association between CTLA-4 60G/A and -1661A/G Polymorphisms and the Risk of Cancers: A Meta-AnalysisPLOS ONE, 2013
- The −319C/+49G/CT60G Haplotype of CTLA-4 Gene Confers Susceptibility to Rheumatoid Arthritis in Mexican PopulationCell Biochemistry and Biophysics, 2013
- Molecular pathways in colorectal cancerJournal of Gastroenterology and Hepatology, 2012
- Interleukin genes and associations with colon and rectal cancer risk and overall survivalInternational Journal of Cancer, 2012
- The soluble CTLA-4 receptor and its role in autoimmune diseases: an updateAutoimmunity Highlights, 2010
- Biomarkers for Colorectal CancerInternational Journal of Molecular Sciences, 2010
- Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han populationBMC Cancer, 2007
- High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancerHuman Immunology, 2007
- Association ofCTLA4 polymorphism with regulatory T cell frequencyEuropean Journal of Immunology, 2005