Extracellular microRNAs as messengers in the central and peripheral nervous system
Open Access
- 2 November 2017
- journal article
- Published by Portland Press Ltd. in Neuronal Signaling
- Vol. 1 (4), NS20170112
- https://doi.org/10.1042/ns20170112
Abstract
MicroRNAs are small post-transcriptional regulators that play an important role in nervous system development, function and disease. More recently, microRNAs have been detected extracellularly and circulating in blood and other body fluids, where they are protected from degradation by encapsulation in vesicles, such as exosomes, or by association with proteins. These microRNAs are thought to be released from cells selectively through active processes and taken up by specific target cells within the same or in remote tissues where they are able to exert their repressive function. These characteristics make extracellular microRNAs ideal candidates for intercellular communication over short and long distances. This review aims to explore the potential mechanisms underlying microRNA communication within the nervous system and between the nervous system and other tissues. The suggested roles of extracellular microRNAs in the healthy and the diseased nervous system will be reviewed.This publication has 156 references indexed in Scilit:
- Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated Neuronal dysfunctionCell Death & Disease, 2012
- Blood serum miRNA: Non-invasive biomarkers for Alzheimer's diseaseExperimental Neurology, 2012
- Regulation of AMPA receptor trafficking and synaptic plasticityCurrent Opinion in Neurobiology, 2012
- MicroRNA networks direct neuronal development and plasticityCellular and Molecular Life Sciences, 2011
- Multivesicular bodies in neurons: Distribution, protein content, and trafficking functionsProgress in Neurobiology, 2011
- Acid sphingomyelinase activity triggers microparticle release from glial cellsThe EMBO Journal, 2009
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseasesCell Research, 2008
- The MicroRNA miR-124 Promotes Neuronal Differentiation by Triggering Brain-Specific Alternative Pre-mRNA SplicingMolecular Cell, 2007
- A Mammalian microRNA Expression Atlas Based on Small RNA Library SequencingCell, 2007