Application of Simplex Lattice Design on the Optimization of Andrographolide Self Nanoemulsifying Drug Delivery System (SNEDDS)
Open Access
- 10 July 2020
- journal article
- research article
- Published by Universitas Gadjah Mada in Indonesian Journal of Pharmacy
- Vol. 31 (2), 124-130
- https://doi.org/10.14499/indonesianjpharm31iss2pp124
Abstract
Background: Optimization of self-nanoemulsifying drug delivery system (SNEDDS) formulation is an important step to obtain optimal formulation with desired characteristics. Objective: This present study was aimed to utilize simplex lattice design in optimizing andrographolide SNEDDS. Method: Simplex lattice design was employed to optimize andrographolide SNEDDS in which component of SNEDDS was selected as the independent factor while the charactheristics of SNEDDS was used as the responses. Capryol-90, Kolliphor RH 40, and propylene glycol were selected as the oil, surfactant, and co-surfactant, respectively. Optimization of andrographolide SNEDDS formulation was based on their characteristics including emulsification time, droplet size, and drug content. The optimized SNEDDS formulation was evaluated for emulsification time, droplet size, drug content, and zeta potensial. Results: The emulsification time, droplet size, drug content, and zeta potensial of the optimized andrographolide SNEDDS was found to be 1.21±0.03 min, 44.02±0.67 nm, 6.69±0.08 mg/g, and -40.63±0.76 mV, respectively.Conclusion: This result suggested that simplex lattice design is a suitable for efficiently optimizing the formulation of andrographolide SNEDDS.Keywords
This publication has 22 references indexed in Scilit:
- Ropivacaine loaded microemulsion and microemulsion-based gel for transdermal delivery: Preparation, optimization, and evaluationInternational Journal of Pharmaceutics, 2014
- Quercetin-Containing Self-Nanoemulsifying Drug Delivery System for Improving Oral BioavailabilityJournal of Pharmaceutical Sciences, 2014
- Impact of various nonionic surfactants on self-nanoemulsification efficiency of two grades of Capryol (Capryol-90 and Capryol-PGMC)Journal of Molecular Liquids, 2013
- Development and Optimization of Self‐Nanoemulsifying Drug Delivery System with Enhanced Bioavailability by Box–Behnken Design and Desirability FunctionJournal of Pharmaceutical Sciences, 2012
- Optimized self nano-emulsifying systems of ezetimibe with enhanced bioavailability potential using long chain and medium chain triglyceridesColloids and Surfaces B: Biointerfaces, 2012
- Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozilInternational Journal of Pharmaceutics, 2012
- Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancerClinical and Experimental Pharmacology and Physiology, 2012
- Formulation, optimization and evaluation of transferosomal gel for transdermal insulin deliverySaudi Pharmaceutical Journal, 2012
- Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P‐glycoproteinJournal of Pharmaceutical Sciences, 2011
- A bitter plant with a sweet future? A comprehensive review of an oriental medicinal plant: Andrographis paniculataPhytochemistry Reviews, 2011