Advances in Hepatitis E Virus Biology and Pathogenesis
Open Access
- 9 February 2021
- Vol. 13 (2), 267
- https://doi.org/10.3390/v13020267
Abstract
Hepatitis E virus (HEV) is one of the causative agents for liver inflammation across the world. HEV is a positive-sense single-stranded RNA virus. Human HEV strains mainly belong to four major genotypes in the genus Orthohepevirus A, family Hepeviridae. Among the four genotypes, genotype 1 and 2 are obligate human pathogens, and genotype 3 and 4 cause zoonotic infections. HEV infection with genotype 1 and 2 mainly presents as acute and self-limiting hepatitis in young adults. However, HEV infection of pregnant women with genotype 1 strains can be exacerbated to fulminant hepatitis, resulting in a high rate of case fatality. As pregnant women maintain the balance of maternal-fetal tolerance and effective immunity against invading pathogens, HEV infection with genotype 1 might dysregulate the balance and cause the adverse outcome. Furthermore, HEV infection with genotype 3 can be chronic in immunocompromised patients, with rapid progression, which has been a challenge since it was reported years ago. The virus has a complex interaction with the host cells in downregulating antiviral factors and recruiting elements to generate a conducive environment of replication. The virus-cell interactions at an early stage might determine the consequence of the infection. In this review, advances in HEV virology, viral life cycle, viral interference with the immune response, and the pathogenesis in pregnant women are discussed, and perspectives on these aspects are presented.Keywords
This publication has 214 references indexed in Scilit:
- Role of novel type I interferon epsilon in viral infection and mucosal immunityMucosal Immunology, 2012
- IL‐28A (IFN‐λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway diseaseEMBO Molecular Medicine, 2011
- IFN-λ determines the intestinal epithelial antiviral host defenseProceedings of the National Academy of Sciences of the United States of America, 2011
- Peroxisomes Are Signaling Platforms for Antiviral Innate ImmunityCell, 2010
- Innate immunityJournal of Allergy and Clinical Immunology, 2010
- Biological and immunological characteristics of hepatitis E virus-like particles based on the crystal structureProceedings of the National Academy of Sciences of the United States of America, 2009
- Hepatitis E and pregnancy: understanding the pathogenesisLiver International, 2008
- Hepatitis E: An emerging awareness of an old diseaseJournal of Hepatology, 2008
- Cellular Immune Responses in Acute Hepatitis E Virus Infection to The Viral Open Reading Frame 2 ProteinViral Immunology, 2007
- T‐cell epitope mapping of ORF2 and ORF3 proteins of human hepatitis E virusJournal of Viral Hepatitis, 2006