Associations of birthweight and history of childhood obesity with beta cell mass in Japanese adults
Open Access
- 1 April 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Diabetologia
- Vol. 63 (6), 1199-1210
- https://doi.org/10.1007/s00125-020-05127-2
Abstract
Aims/hypothesis Low birthweight is associated with a high risk of diabetes, but there are no reports discussing birthweight and pancreatic tissues in humans. The purpose of this study was to examine the correlation between birthweight and beta and alpha cell mass in humans. Methods Sixty-four Japanese adults with and without diabetes who underwent pancreatectomy and were able to recall their weight history including birthweight were included. Pancreatic tissues were stained for insulin and glucagon, and fractional beta cell area (BCA) and alpha cell area (ACA) were quantified. Islet size and density and beta cell replication were also quantified and their associations with birthweight were evaluated. Results In participants without diabetes, there was a weak positive correlation between birthweight and BCA (R = 0.34, p = 0.03). The group with a history of childhood obesity, but not the group with a history of obesity in adulthood only, showed higher BCA compared with those without a history of obesity (1.78 ± 0.74% vs 0.99 ± 0.53%, p = 0.01), and the correlation coefficient between birthweight and BCA increased after excluding those with a history of childhood obesity (R = 0.51, p < 0.01). In those with diabetes, there was no correlation between birthweight and BCA. No correlation was found between birthweight and ACA in either those with or without diabetes. Conclusions/interpretation Birthweight and beta, but not alpha, cell mass are positively correlated in non-diabetic adults, and a history of childhood obesity may affect beta cell mass. Graphical abstractFunding Information
- Ministry of Education, Culture, Sports, Science and Technology (18K08488)
This publication has 48 references indexed in Scilit:
- Role of pancreatic duct cell in beta cell neogenesis: A mini review studyDiabetes & Metabolic Syndrome: Clinical Research & Reviews, 2017
- Effects of Obesity and Diabetes on α- and β-Cell Mass in Surgically Resected Human PancreasJournal of Clinical Endocrinology & Metabolism, 2016
- β-cell dysfunction: Its critical role in prevention and management of type 2 diabetesWorld Journal of Diabetes, 2015
- β-Cell Mass and Turnover in HumansDiabetes Care, 2012
- Low BMI at age 20 years predicts gestational diabetes independent of BMI in early pregnancy in Japan: Tanaka Women’s Clinic StudyDiabetic Medicine, 2012
- Life-course weight characteristics and the risk of gestational diabetesDiabetologia, 2009
- The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysisBMC Public Health, 2009
- Worldwide trends in childhood overweight and obesityPediatric Obesity, 2006
- The Fetal and Childhood Growth of Persons Who Develop Type 2 DiabetesAnnals of Internal Medicine, 2000
- Birth Weight, Adult Weight, and Girth as Predictors of the Metabolic Syndrome in Postmenopausal Women: The Rancho Bernardo StudyDiabetes Care, 1998