An independent component analysis reveals brain structural networks related to TNF-α in drug-naïve, first-episode major depressive disorder: a source-based morphometric study
Open Access
- 10 June 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Translational Psychiatry
- Vol. 10 (1), 1-7
- https://doi.org/10.1038/s41398-020-00873-8
Abstract
In a previous mouse study, social defeat stress-induced microglial activation released tumor necrosis factor-α (TNF-α), leading to neuronal changes in the prefrontal cortex (PFC) and behavioral changes (anxiety). We aimed to investigate the relationship between gray-matter (GM) structural networks and serum TNF-α in patients with major depression disorder (MDD) using multivariate source-based morphometry (SBM). Forty-five first-episode and drug-naïve MDD patients and 38 healthy subjects (HSs) were recruited. High-resolution T1-weighted imaging was performed and serum TNF-α levels were measured in all MDD patients and HSs. After acquiring GM structural networks using SBM, we compared the Z-transformed loading coefficients (Z-scores) between MDD patients and HSs, and investigated the relationship between the Z-scores and the serum TNF-α levels in MDD patients. The serum TNF-α levels in MDD patients were significantly higher than those in HSs. We extracted two independent GM structural networks (the prefrontal network and the insula-temporal network) with significant differences between MDD patients and HSs (−0.305 ± 0.85 and 0.253 ± 0.82; P = 0.03 in the prefrontal network, and −0.268 ± 0.86 and 0.467 ± 0.71; P < 0.01 in the insula-temporal network). The serum TNF-α levels were significantly correlated with the Z-scores in the prefrontal network after Bonferroni correction (r = −0.419, p < 0.01); however, the correlation in the insula-temporal network was not significant (r = −0.290, p = 0.11). Elevated serum TNF-α levels in the early stage of MDD were associated with alteration of the prefrontal network.This publication has 49 references indexed in Scilit:
- The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial ActivationNeuron, 2018
- Morphometric Similarity Networks Detect Microscale Cortical Organization and Predict Inter-Individual Cognitive VariationNeuron, 2017
- A Toolkit for Clinical Statisticians to Fix Problems Based on Biomarker Measurements Subject to Instrumental Limitations: From Repeated Measurement Techniques to a Hybrid Pooled–Unpooled DesignMethods in Molecular Biology, 2014
- Regional increases of cortical thickness in untreated, first-episode major depressive disorderTranslational Psychiatry, 2014
- Peripheral elevation of TNF-α leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitisProceedings of the National Academy of Sciences of the United States of America, 2013
- Impaired Development and Competitive Refinement of the Cortical Frequency Map in Tumor Necrosis Factor- -Deficient MiceCerebral Cortex, 2013
- Computational anatomy with the SPM softwareMagnetic Resonance Imaging, 2009
- Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major DepressionBiological Psychiatry, 2009
- Tumor Necrosis Factor-α Mediates One Component of Competitive, Experience-Dependent Plasticity in Developing Visual CortexNeuron, 2008
- An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interestNeuroImage, 2006