Conserved Upstream Open Reading Frame Nascent Peptides That Control Translation
- 23 November 2020
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genetics
- Vol. 54 (1), 237-264
- https://doi.org/10.1146/annurev-genet-112618-043822
Abstract
Cells utilize transcriptional and posttranscriptional mechanisms to alter gene expression in response to environmental cues. Gene-specific controls, including changing the translation of specific messenger RNAs (mRNAs), provide a rapid means to respond precisely to different conditions. Upstream open reading frames (uORFs) are known to control the translation of mRNAs. Recent studies in bacteria and eukaryotes have revealed the functions of evolutionarily conserved uORF-encoded peptides. Some of these uORF-encoded nascent peptides enable responses to specific metabolites to modulate the translation of their mRNAs by stalling ribosomes and through ribosome stalling may also modulate the level of their mRNAs. In this review, we highlight several examples of conserved uORF nascent peptides that stall ribosomes to regulate gene expression in response to specific metabolites in bacteria, fungi, mammals, and plants.Keywords
This publication has 159 references indexed in Scilit:
- Arginine Changes the Conformation of the Arginine Attenuator Peptide Relative to the Ribosome TunnelJournal of Molecular Biology, 2012
- Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to Enhance CHOP TranslationOnline Journal of Public Health Informatics, 2011
- Recruitment of a species-specific translational arrest module to monitor different cellular processesProceedings of the National Academy of Sciences of the United States of America, 2011
- Sequence Requirements for Ribosome Stalling by the Arginine Attenuator PeptideOnline Journal of Public Health Informatics, 2010
- Initiation context modulates autoregulation of eukaryotic translation initiation factor 1 (eIF1)Proceedings of the National Academy of Sciences of the United States of America, 2010
- Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug actionProceedings of the National Academy of Sciences of the United States of America, 2010
- A ribosome–nascent chain sensor of membrane protein biogenesis in Bacillus subtilisThe EMBO Journal, 2009
- The Plasticity of a Translation Arrest Motif Yields Insights into Nascent Polypeptide Recognition inside the Ribosome TunnelMolecular Cell, 2009
- Expression patterns within the Arabidopsis C/S1 bZIP transcription factor network: availability of heterodimerization partners controls gene expression during stress response and developmentPlant Molecular Biology, 2008
- uORFs with unusual translational start codons autoregulate expression of eukaryotic ornithine decarboxylase homologsProceedings of the National Academy of Sciences of the United States of America, 2008