Targeting BCL-2 proteins in pediatric cancer: Dual inhibition of BCL-XL and MCL-1 leads to rapid induction of intrinsic apoptosis
- 10 July 2020
- journal article
- research article
- Published by Elsevier BV in Cancer Letters
- Vol. 482, 19-32
- https://doi.org/10.1016/j.canlet.2020.02.041
Abstract
No abstract availableKeywords
Funding Information
- Deutsche Krebshilfe
- BMBF
- Medical Faculty, Goethe-University Frankfurt
This publication has 47 references indexed in Scilit:
- ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing plateletsNature Medicine, 2013
- Understanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease ProgressionFrontiers in Oncology, 2013
- Cell Death Pathways as Therapeutic Targets in RhabdomyosarcomaSarcoma, 2012
- Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-xL/Bcl-2 in Mcl-1–expressing myeloma cellsBlood, 2011
- Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell linesOncogene, 2010
- The landscape of somatic copy-number alteration across human cancersNature, 2010
- Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975‐2005Cancer, 2009
- Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liverHepatology, 2009
- Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytesHepatology, 2008
- Expression of receptor tyrosine kinases and apoptotic molecules in rhabdomyosarcomaCancer, 2007