Detection of Urinary Molecular Marker Test in Urothelial Cell Carcinoma: A Review of Methods and Accuracy
Open Access
- 4 November 2022
- journal article
- review article
- Published by MDPI AG in Diagnostics
- Vol. 12 (11), 2696
- https://doi.org/10.3390/diagnostics12112696
Abstract
Early detection of bladder cancer has a positive impact on prognosis. A variety of biomarkers have been developed to detect bladder tumors in urine early and reduce the need for cystoscopy. To detect bladder cancer, several methods are available, but their accuracy varies according to the sensitivity and specificity of each method. This review aims to highlight the established detection methods for bladder cancer based on the available literature. In addition, we aim to identify the combination of different effective detection methods that provides the highest degree of accuracy. In our study, a keyword retrieval method was used to search for appropriate English-language references. This bibliography has been indexed in PubMed and Scopus or has been found through systematic searches from 2015 to 2022. Based on an analysis of international guidelines, it has been revealed that there are numerous discrepancies and unresolved issues. The discovery of an ideal detection method for urothelial cell carcinoma biomarkers has been the subject of numerous efforts. In recent years, a wide range of off-label, experimental, novel, and combined approaches have been published on this topic. This review can contribute to the identification of accurate methods of detecting bladder cancer and highlight areas for future research that can be improved.Keywords
This publication has 52 references indexed in Scilit:
- Urinary Biomarkers for Diagnosis of Bladder CancerAnnals of Internal Medicine, 2015
- MSIseq: Software for Assessing Microsatellite Instability from Catalogs of Somatic MutationsScientific Reports, 2015
- Management of carcinoma in situ of the bladder: best practice and recent developmentsTherapeutic Advances in Urology, 2015
- Prospective analysis of sensitivity and specificity of urinary cytology and other urinary biomarkers for bladder cancerUrologic Oncology, 2015
- Biomarkers for non-muscle invasive bladder cancer: Current tests and future promiseIndian Journal of Urology, 2015
- Diagnostics techniques in nonmuscle invasive bladder cancerIndian Journal of Urology, 2015
- Molecular biomarkers in urothelial bladder cancerCancer Science, 2008
- Urine Markers for Bladder Cancer Surveillance: A Systematic ReviewEuropean Urology, 2005
- Tumor Markers in the Diagnosis of Primary Bladder Cancer. A Systematic ReviewJournal of Urology, 2003
- CAN URINE BOUND DIAGNOSTIC TESTS REPLACE CYSTOSCOPY IN THE MANAGEMENT OF BLADDER CANCER?Journal of Urology, 1998