Epigenetics in neurodegenerative disorders induced by pesticides
Open Access
- 10 December 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Genes and Environment
- Vol. 43 (1), 1-12
- https://doi.org/10.1186/s41021-021-00224-z
Abstract
Neurodegenerative diseases are becoming major socio-economic burdens. However, most of them still have no effective treatment. Growing evidence indicates excess exposure to pesticides are involved in the development of various forms of neurodegenerative and neurological diseases through trigger epigenetic changes and inducing disruption of the epigenome. This review summaries studies on epigenetics alterations in nervous systems in relation to different kinds of pesticides, highlighting potential mechanism in the etiology, precision prevention and target therapy of various neurodegenerative diseases. In addition, the current gaps in research and future areas for study were also discussed.Keywords
Funding Information
- National Natural Science Foundation of China (81973083, 81903352, 22006019, 82173553)
- the Joint Funds for the innovation of science and Technology, Fujian province (2017Y9105, 2018Y9098, 2019Y9020)
- the Provincial Natural Science Foundation of Fujian Province (2020J02021, 2019J05081)
- Natural Science Foundation of Zhejiang Province (LQ19H260002)
- Ningbo Natural Science Foundation (2018A610317)
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