CLINICAL CHARACTERISTICS, LABORATORY TESTS AND TREATMENT OUTCOME IN PATIENTS WITH ACUTE RESPIRATORY FAILURE REQUIRING INVASIVE MECHANICAL VENTILATOR IN INTENSIVE CARE UNIT AT HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL

Abstract

Ojectives: 1. To describe the clinical and subclinical characteristics of patients with acute respiratory failure requiring invasive ventilation. 2. To evaluate the outcome of acute respiratory failure treatment with invasive ventilation and factors related to treatment failure. Materials and Method: 51 patients diagnosed with acute respiratory failure requiring invasive mechanical ventilation in ICU at Hue University of Medicine and Pharmacy Hospital. The prospective cohort study. Results: The mean age was 69.6 ± 16.4. Tachypnea and agitation were the most common sign (51%). The mean APACHE II score was 20.2 ± 3.3. The mortality rate was 33.3%. The variables associated with treatment failure were age ≥ 70 tuổi (RR = 2.7; p < 0.05), history of chronic kidney disease (RR = 2.9; p < 0.05), sepsis as a cause of mechanical ventilation (RR = 2.5; p < 0.05), ventilator-associated pneumonia (RR = 2.4; p < 0.05) and renal dysfunction during treatment (RR =2.4; p < 0.05). Conclusion: The clinical characteristics of ARF patients requiring IMV were various and the mortality rate remained high. Risk factors for treatment failure included age ≥ 70, history of chronic kidney disease, sepsis as a cause of mechanical ventilation, ventilator-associated pneumonia and renal dysfunction during treatment. Keywords: acute respiratory failure, invasive ventilation, invasive mechanical ventilation