Effects of Exercise on Cancer Treatment Efficacy: A Systematic Review of Preclinical and Clinical Studies
Open Access
- 30 September 2021
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 81 (19), 4889-4895
- https://doi.org/10.1158/0008-5472.CAN-21-1258
Abstract
We systematically reviewed and synthesized evidence on the impact of physical activity/exercise on cancer treatment efficacy. We included six preclinical and seven clinical studies. Exercise significantly enhanced the efficacy of chemotherapy and tamoxifen in seven of eight rodent models in either an additive, sensitizing, or synergistic manner. In clinical studies, preliminary evidence indicates that exercise during neoadjuvant, primary, and adjuvant treatment may enhance efficacy of cancer therapies; however, no clinical study was designed for this purpose. Here we discuss the biological mechanisms of exercise-associated enhancement of therapeutic efficacy and propose future research directions to definitively examine the effects of exercise on cancer treatment and patient outcomes.Funding Information
- Canadian Cancer Society (#707046)
- Canada Research Chairs Program
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