Heavy‐Atom‐Modulated Supramolecular Assembly Increases Antitumor Potency against Malignant Breast Tumors via Tunable Cooperativity
- 3 December 2020
- journal article
- research article
- Published by Wiley in Advanced Materials
- Vol. 33 (2), e2004225
- https://doi.org/10.1002/adma.202004225
Abstract
Triple‐negative breast cancer (TNBC) remains with highest incidence and mortality rates among females, and a critical bottleneck lies in rationally establishing potent therapeutics against TNBC. Here, the self‐assembled micellar nanoarchitecture of heavy‐atom‐modulated supramolecules with efficient cytoplasmic translocation and tunable photoconversion is shown, for potent suppression against primary, metastatic, and recurrent TNBC. Multi‐iodinated boron dipyrromethene micelles yield tunable photoconversion into singlet oxygen and a thermal effect, together with deep penetration and subsequent cytoplasmic translocation at the tumor. Tetra‐iodinated boron dipyrromethene micelles (4‐IBMs) particularly show a distinctly enhanced cooperativity of antitumor efficiency through considerable expressions of apoptotic proteins, potently suppressing subcutaneous, and orthotopic TNBC models, together with reduced oxygen dependence. Furthermore, 4‐IBMs yield preferable anti‐metastatic and anti‐recurrent efficacies through the inhibition of metastasis‐relevant proteins, distinct immunogenic cell death, and re‐education of M2 macrophages into tumoricidal M1 phenotype as compared to chemotherapy and surgical resection. These results offer insights into the cooperativity of supramolecular nanoarchitectures for potent phototherapy against TNBC.Funding Information
- National Basic Research Program of China (2014CB931900)
- National Natural Science Foundation of China (51873143, 31671016, 31771089, 31971298)
- Priority Academic Program Development of Jiangsu Higher Education Institutions
This publication has 60 references indexed in Scilit:
- Clinical significance of pAkt and pErk1/2 expression in early-stage breast cancer patients treated with anthracycline-based adjuvant chemotherapyOncology Letters, 2015
- Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivoNature Communications, 2015
- Self-assembled micellar nanocomplexes comprising green tea catechin derivatives and protein drugs for cancer therapyNature Nanotechnology, 2014
- Functional Nanomaterials for Phototherapies of CancerChemical Reviews, 2014
- Thermal ablation of tumours: biological mechanisms and advances in therapyNature Reviews Cancer, 2014
- Polyion Complex Vesicles for Photoinduced Intracellular Delivery of Amphiphilic PhotosensitizerJournal of the American Chemical Society, 2013
- A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signalsNature Materials, 2013
- Dynamic metabolic labeling of DNA in vivo with arabinosyl nucleosidesProceedings of the National Academy of Sciences of the United States of America, 2011
- Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on sizeNature Nanotechnology, 2011
- Hypoxia in cancer: significance and impact on clinical outcomeCancer and Metastasis Reviews, 2007