Enantioselective Three‐Component Coupling of Heteroarenes, Cycloalkenes and Propargylic Acetates
- 1 December 2020
- journal article
- research article
- Published by Wiley in Angewandte Chemie
- Vol. 60 (9), 4491-4495
- https://doi.org/10.1002/anie.202014781
Abstract
Asymmetric coupling proceeds efficiently between propargylic acetates, cycloalkenes and electron‐rich heteroarenes including indoles, pyrroles, activated furans and thiophens. 2,3‐Disubstituted tetrahydrofurans and pyrrolidines are produced in trans configuration and excellent enantiomeric ratios. The reaction proceeds via Wacker‐type attack of heteroarenes on alkenes activated by electron‐deficient Pd(II) species.Funding Information
- Science and Engineering Research Council (AME IRG A1783c0010)
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