Clinical profile of patients with AKI and liver cirrhosis attending tertiary care hospital

Abstract

Despite improved understanding of precipitants and physiology of underlying AKI in cirrhosis, considerable confusion still continues to surround its diagnosis due to arbitrary use of creatinine which is effected by several factors like diet, volume status, protein intake, muscle mass, interference with assays of creatinine by elevated bilirubin level making traditional criteria of AKI with serum creatinine greater than 1.5 gm/dl not suitable as diagnostic criteria as it can delay the detection of AKI, further delaying treatment & prognosis. All participating patients of either gender admitted in department of GASTROENTEROLOGY with age >18 years with either diagnosed or newly diagnosed case of cirrhosis of liver (Including both compensated & decompensated cases) admitted with acute kidney injury diagnosed according to International Club of Ascites Classification were enrolled in this study. 64.9% of patients with AKI in the study had MELD score between 16-30 followed by 23.4% & 11.7% in MELD > 30 & MELD