Cutaneous pseudolymphoma: A clinicopathological study and immunohistochemical patterns
Open Access
- 1 January 2021
- journal article
- research article
- Vol. 12 (3), 283-289
- https://doi.org/10.22088/cjim.12.3.283
Abstract
Background: Cutaneous pseudolymphoma can histologically and clinically simulate various types of cutaneous lymphoma. We conducted the current study to evaluate the clinicopathological and immunohistochemical (IHC) aspects of cutaneous pseudolymphoma (PSL). Methods: 30 cases of cutaneous PSL were selected from the archives of 2013-2017 in Shahid Faghihi Hospital pathology lab, Shiraz University of Medical Sciences. Available clinical data, histopathological features and IHC findings were statistically analyzed. Results: The female: male ratio was 2:1 and the median age was 47 +/- 14.9 years. The lesions were located on the head and neck 26 (86.7%), trunk 2 (6.7%) and extremities 2 (6.7%). 23 (76.7%) cases had nodular pattern, while 7 (23.3%) showed diffuse pattern. The grenz zone was seen in 24 (80%) cases. Sixteen (53.3%) cases showed top heavy infiltration, 11 (36.7%) showed the same distribution of infiltration at the superficial and deep dermis, often involving the subcutaneous fat and 3(10%) showed bottom heavy infiltration. In IHC, 11(36.6%) cases showed the B cell type, 10 (33.3%) T cell type and 9 (30%) mixed type (B and T cells). Conclusion: None of the cases was suspicious for cutaneous lymphoma, applying IHC staining. Gender distribution, and the site of cutaneous lesions were similar to previous studies. The most common histological subtype was nodular, while the B-cell cutaneous pseudolymphoma was slightly more common compared to the T-cell type.This publication has 14 references indexed in Scilit:
- A General Approach to the Diagnosis of Cutaneous Lymphomas and PseudolymphomasSurgical Pathology Clinics, 2014
- Cutaneous pseudolymphomas: inflammatory reactive proliferationsExpert Review of Hematology, 2013
- Cutaneous pseudolymphoma: a case report with an immunohistochemical study.2013
- Acral Pseudolymphomatous Angiokeratoma of ChildrenThe American Journal of Dermatopathology, 2012
- Skin as a Peripheral Lymphoid Organ: Revisiting the Concept of Skin-Associated Lymphoid TissuesJournal of Investigative Dermatology, 2011
- A study of histologic and immunophenotypical staining patterns in cutaneous lymphoid hyperplasiaJournal of the American Academy of Dermatology, 2011
- WHAT IS PSEUDOLYMPHOA AND ITS NATUREJournal of IMAB – Annual Proceeding (Scientific Papers), 2011
- Pseudoclonality in cutaneous pseudolymphomas: a pitfall in interpretation of rearrangement studiesBritish Journal of Dermatology, 2008
- Cutaneous B-cell Pseudolymphoma at the Site of VaccinationThe American Journal of Dermatopathology, 2007
- A review of 55 cases of cutaneous lymphoid hyperplasia: reassessment of the histopathologic findings leading to reclassification of 4 lesions as cutaneous marginal zone lymphoma and 19 as pseudolymphomatous folliculitisHuman Pathology, 2005