The association between genome-wide polymorphisms and chronic postoperative pain: a prospective observational study
Open Access
- 1 January 2020
- journal article
- research article
- Published by Wiley in Anaesthesia
- Vol. 75 (S1), E111-E120
- https://doi.org/10.1111/anae.14832
Abstract
Chronic postoperative pain is common and can have a negative impact on quality of life. Recent studies show that genetic risk factors are likely to play a role, although only gene-targeted analysis has been used to date. This is the first genome-wide association study to identify single-nucleotide polymorphisms associated with the development of chronic postoperative pain based on two independent cohorts. In a discovery cohort, 330 women scheduled for hysterectomy were genotyped. A case-control association analysis compared patients without chronic postoperative pain and the 34 who had severe chronic postoperative pain 3 months after surgery. No single-nucleotide polymorphisms reached genome-wide significance, but several showed suggestive associations with chronic postoperative pain (p < 1 x 10(-5)). Single-nucleotide polymorphisms with significance p NAV3 was significantly replicated with chronic postoperative pain in the replication cohort (p = 0.009). Meta-analysis revealed that two loci (IQGAP1 and CRTC3) were significantly associated with chronic postoperative pain at 3 months (IQGAP1 p = 3.93 x 10(-6) beta = 2.3863, CRTC3 p = 2.26 x 10(-6), beta = 2.4209). The present genome-wide association study provides initial evidence for genetic risk factors of chronic postoperative pain and supports follow-up studies.This publication has 48 references indexed in Scilit:
- Economic and humanistic burden of post-trauma and post-surgical neuropathic pain among adults in the United StatesJournal of Pain Research, 2013
- CRTC3 links catecholamine signalling to energy balanceNature, 2010
- Multiple chronic pain states are associated with a common amino acid–changing allele in KCNS1Brain, 2010
- LocusZoom: regional visualization of genome-wide association scan resultsBioinformatics, 2010
- Aberrant microRNA expression in the brains of neurodegenerative diseases: miR‐29a decreased in Alzheimer disease brains targets neurone navigator 3Neuropathology and Applied Neurobiology, 2010
- Evidence for a biopsychosocial influence on shoulder pain: Pain catastrophizing and catechol- O -methyltransferase (COMT) diplotype predict clinical pain ratingsPain, 2008
- PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage AnalysesAmerican Journal of Human Genetics, 2007
- A new multipoint method for genome-wide association studies by imputation of genotypesNature Genetics, 2007
- Multivariate Genetic Analysis of Chronic Pelvic Pain and Associated PhenotypesBehavior Genetics, 2005
- Genome-wide association studies for common diseases and complex traitsNature Reviews Genetics, 2005