AMTRA: a multicentered experience of a web-based monitoring and tailored toxicity management system for cancer patients
- 1 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Supportive Care in Cancer
- Vol. 29 (2), 859-867
- https://doi.org/10.1007/s00520-020-05550-6
Abstract
Background Technology-based interventions are increasingly being introduced in routine clinical cancer care. There is a need for reliable systems to monitor treatment-related toxicity in a standardized manner. Such electronic tools bridge the gap in providing quality home-based monitoring. Methods From July 2017 to December 2017, we performed a multicentered, non-randomized prospective cohort analysis with patients who were receiving routine chemotherapy for various solid tumors, using a web-based patient-reported toxicity registration, management, and intervention system called AMTRA (ambulatory Monitoring of cancer Therapy using an interactive Application) linked to the homecare nursing organization Remedus (R). Twelve common toxicities plus pain and two biometrics could be registered daily or more frequently as required. These were processed centrally to generate tailored advice for lesser symptoms or a phone call from a dedicated nurse in case of severe or prolonged toxicity. A compliance tool to monitor oral therapies was incorporated in the system. Results One hundred sixty-eight patients (92%) were enrolled, with 31,514 registrations analyzed. One hundred eight patients reported severe toxicity (> 1461 registrations), resulting in 102 clinical interventions ranging from self-management advice, supplemental consultations to hospitalizations. Compliance to oral chemotherapy was high using AMTRA with a median of 98.7% (95 confidence interval (CI) [93.5-100.0%]). Seventy-nine percent of patients stated that the availability of AMTRA self-reports was useful in communication with the care provider, while 75% felt more in control while managing their treatment. Conclusions The application of an interactive PRO-system in routine symptom management of cancer patients allowed standardized documentation of toxicities and recorded a high compliance with oral treatment. It allows for rapid interaction for toxicities and cancer-related symptoms experienced at home.Funding Information
- Belgian Federal Goverment (ehealt initiative)
This publication has 33 references indexed in Scilit:
- Tell Us™: A Web-Based Tool for Improving Communication Among Patients, Families, and Providers in Hospice and Palliative Care Through Systematic Data Specification, Collection, and UseJournal of Pain and Symptom Management, 2011
- Adverse Symptom Event Reporting by Patients vs Clinicians: Relationships With Clinical OutcomesJNCI Journal of the National Cancer Institute, 2009
- PatientViewpoint: a website for patient-reported outcomes assessmentQuality of Life Research, 2009
- Patients' perceptions and experiences of using a mobile phone-based advanced symptom management system (ASyMS©) to monitor and manage chemotherapy related toxicityEuropean Journal of Cancer Care, 2009
- Patient reported outcome measures: a model-based classification system for research and clinical practiceQuality of Life Research, 2008
- Development, Validation, and Use of English and Spanish Versions of the Telemedicine Satisfaction and Usefulness QuestionnaireJournal of the American Medical Informatics Association, 2006
- Impact of patient‐reported outcome measures on routine practice: a structured reviewJournal of Evaluation in Clinical Practice, 2006
- Patient Online Self-Reporting of Toxicity Symptoms During ChemotherapyJournal of Clinical Oncology, 2005
- Emergency Department Waiting Times for Patients With Cancer With Febrile Neutropenia: A Pilot StudyOncology Nursing Forum, 2004
- The measurement of clinical pain intensity: a comparison of six methodsPain, 1986