Long-lasting severe immune dysfunction in Ebola virus disease survivors
Open Access
- 24 July 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Communications
- Vol. 11 (1), 1-11
- https://doi.org/10.1038/s41467-020-17489-7
Abstract
Long-term follow up studies from Ebola virus disease (EVD) survivors (EBOV_S) are lacking. Here, we evaluate immune and gene expression profiles in 35 Guinean EBOV_S from the last West African outbreak, a median of 23 months (IQR [18–25]) after discharge from treatment center. Compared with healthy donors, EBOV_S exhibit increases of blood markers of inflammation, intestinal tissue damage, T cell and B cell activation and a depletion of circulating dendritic cells. All survivors have EBOV-specific IgG antibodies and robust and polyfunctional EBOV-specific memory T-cell responses. Deep sequencing of the genes expressed in blood reveals an enrichment in ‘inflammation’ and ‘antiviral’ pathways. Integrated analyses identify specific immune markers associated with the persistence of clinical symptoms. This study identifies a set of biological and genetic markers that could be used to define a signature of “chronic Ebola virus disease (CEVD)”.This publication has 47 references indexed in Scilit:
- CD56negCD16+NK cells are activated mature NK cells with impaired effector function during HIV-1 infectionRetrovirology, 2013
- ZnT8-Specific CD4+ T Cells Display Distinct Cytokine Expression Profiles between Type 1 Diabetes Patients and Healthy AdultsPLOS ONE, 2013
- SPICE: Exploration and analysis of post‐cytometric complex multivariate datasetsCytometry Part A, 2011
- Expansion of Functionally Skewed CD56-Negative NK Cells in Chronic Hepatitis C Virus Infection: Correlation with Outcome of Pegylated IFN-α and Ribavirin TreatmentThe Journal of Immunology, 2009
- A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus ErythematosusImmunity, 2008
- The mucosal barrier and immune activation in HIV pathogenesisCurrent Opinion in HIV and AIDS, 2008
- Depletion of Peripheral Blood T Lymphocytes and NK Cells During the Course of Ebola Hemorrhagic Fever in Cynomolgus MacaquesViral Immunology, 2004
- Pathogenesis of Ebola Hemorrhagic Fever in Primate Models: Evidence that Hemorrhage Is Not a Direct Effect of Virus-Induced Cytolysis of Endothelial CellsThe American Journal of Pathology, 2003
- Late Ophthalmologic Manifestations in Survivors of the 1995 Ebola Virus Epidemic in Kikwit, Democratic Republic of the CongoThe Journal of Infectious Diseases, 1999
- Role of Epidermal Growth Factor in Gastroduodenal Mucosal ProtectionJournal of Clinical Gastroenterology, 1988