Seroprevalence of hepatitis B virus infection, anti-HCV antibodies and HIV and knowledge among people who use drugs attending methadone therapy clinic in Tanzania; a cross-sectional study
Open Access
- 21 July 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Infectious Diseases
- Vol. 21 (1), 1-9
- https://doi.org/10.1186/s12879-021-06393-0
Abstract
Methadone therapy clinics have been recently introduced in Tanzania, aiming at reducing risk behaviors and infection rates of viral hepatitis and HIV among people who use drugs. The objective of this study was to estimate the prevalence, associated factors and knowledge level of these conditions among people who use drugs attending a methadone clinic in Tanzania. We enrolled 253 People who using drugs receiving Methadone therapy. Clinical data was retrospectively collected from the medical records and face-to face interviews were conducted to determine the behavioral risk factors and respondents’ knowledge on viral hepatitis and HIV. An overall seroprevalence of viral hepatitis (either hepatitis B surface antigen or anti-hepatitis C virus) was 6.3%, while that of hepatitis B virus mono infection was 3.5% and anti-hepatitis C antibodies was 3.5%. Seroprevalence of HIV was 12.6%. Viral hepatitis was strongly predicted by advanced age (> 35 years) (p = 0.02) and staying at Kirumba area (p = 0.004), and HIV infection was predicted by increased age (> 37 years) (p = 0.04) and female sex (p < 0.001). Regarding the knowledge of viral hepatitis, majority of the respondents were unaware of the transmission methods and availability of hepatitis B virus vaccines and only 17% were classified as well informed (provided ≥4 correct answers out of 7 questions). Good knowledge was highly predicted by higher education level of the individual (p = 0.001). Despite the efforts to curb viral hepatitis and HIV infections through Methadone clinics, infection rates among people who use drugs are still high and the general knowledge on preventive measures is inadequate.This publication has 25 references indexed in Scilit:
- Global prevalence of injecting drug use and sociodemographic characteristics and prevalence of HIV, HBV, and HCV in people who inject drugs: a multistage systematic reviewThe Lancet. Global Health, 2017
- Prevalence and predictors of HCV among a cohort of opioid treatment patients in Dar es Salaam, TanzaniaInternational Journal of Drug Policy, 2017
- Prevalence and Predictors of Human Immunodeficiency Virus and Selected Sexually Transmitted Infections Among People Who Inject Drugs in Dar es Salaam, Tanzania: A New Focus to Get to ZeroSexually Transmitted Diseases, 2017
- Identifying mechanisms for facilitating knowledge to action strategies targeting the built environmentBMC Public Health, 2017
- Improvements in health-related quality of life among methadone maintenance clients in Dar es Salaam, TanzaniaInternational Journal of Drug Policy, 2016
- Prevalence of hepatitis B virus infection among health care workers in a tertiary hospital in TanzaniaBMC Infectious Diseases, 2015
- Impact of methadone maintenance on health utility, health care utilization and expenditure in drug users with HIV/AIDSInternational Journal of Drug Policy, 2013
- Methadone Maintenance Therapy Outcomes in IranSubstance Use & Misuse, 2012
- Knowledge About Hepatitis-C Among Methadone Maintenance Treatment Patients in IsraelSubstance Use & Misuse, 2009
- Full participation in harm reduction programmes is associated with decreased risk for human immunodeficiency virus and hepatitis C virus: evidence from the Amsterdam Cohort Studies among drug usersAddiction, 2007