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PEG-400: An efficient and recyclable reaction medium for the synthesis of pyrazolo[1,5-a]pyrimidines

Shankaraiah Guruvaiah Konda
Published: 31 December 2014
European Journal of Chemistry , Volume 5; doi:10.5155/eurjchem.5.4.676-680.1110

Abstract: An efficient and convenient route is described for the synthesis of new pyrazolo [1,5-a] pyrimidine derivatives by the reaction of 4-(4’-chloro-phenylazo)-5-amino pyrazole with α,β-unsaturated carbonyl compounds (chalcones) using polyethylene glycol (PEG-400) as benign reaction medium. The advantage of this protocol includes the excellent yields, operational simplicity, short reaction times and avoidance of volatile organic solvents and expensive catalysts.
Keywords: PEG / Reaction Medium / Recyclable Reaction / pyrimidines / pyrazolo / Synthesis / efficient

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