Review: transcriptome and trans-omics analysis of systemic lupus erythematosus
Open Access
- 18 June 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Inflammation and Regeneration
- Vol. 40 (1), 1-6
- https://doi.org/10.1186/s41232-020-00123-w
Abstract
Systemic lupus erythematosus (SLE), which was recognized as a defined clinical entity more than 100 years ago, is an archetype for systemic autoimmune diseases. The 10-year survival of SLE patients has shown dramatic improvement during the last half-century. However, SLE patients receiving long-term prednisone therapy are at high risk of morbidity due to organ damage. Identification of key immune pathways is mandatory to develop a suitable therapy and to stratify patients based on their responses to therapy. Recently developed transcriptome and omic analyses have revealed a number of immune pathways associated with systemic autoimmunity. In addition to type I interferon, plasmablast and neutrophil signatures demonstrate associations with the SLE phenotype. Systematic investigations of these findings enable us to understand and stratify SLE according to the clinical and immunological features.Keywords
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