RNA-binding proteins in tumor progression
Open Access
- 11 July 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Journal of Hematology & Oncology
- Vol. 13 (1), 1-23
- https://doi.org/10.1186/s13045-020-00927-w
Abstract
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and important biological functions. They are critical to maintain the transcriptome through post-transcriptionally controlling the processing and transportation of RNA, including regulating RNA splicing, polyadenylation, mRNA stability, mRNA localization, and translation. Alteration of each process will affect the RNA life cycle, produce abnormal protein phenotypes, and thus lead to the occurrence and development of tumors. Here, we summarize RBPs involved in tumor progression and the underlying molecular mechanisms whereby they are regulated and exert their effects. This analysis is an important step towards the comprehensive characterization of post-transcriptional gene regulation involved in tumor progression.Keywords
Funding Information
- National Natural Science Foundation of China (81903857, 81702957)
- the Special Postdoctoral Funding Scheme of China (2019T120485)
- Postdoctoral Research Foundation of China (2017M620230)
- Basic Scientific Research Business Expense Project of China Pharmaceutical University (2632020ZD10)
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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